Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status Prescription; Discontinued
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 49452-3917; 68981-031; 82348-102; 0276-0504; 12660-0006; 69336-127; 12854-516; 43235-0010; 63275-9996; 51927-0057; 76465-0001; 51927-0025; 51552-0307; 63187-018; 38779-0078; 51927-0231; 0395-8056; 45865-485; 38779-3039; 49452-3924; 0378-8200; 79572-019; 51604-0011
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Gastrointestinal toxicityTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Gastrointestinal toxicityGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pancytopenia01.03.03.0030.008278%Not Available
Paraesthesia17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Periorbital oedema06.08.03.017; 23.04.01.002; 10.01.05.0100.016556%
Peripheral vascular disorder24.03.01.003--Not Available
Personality disorder19.05.02.002--Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.012417%Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pilonidal cyst23.09.01.012; 11.01.12.0120.008278%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Premature baby18.04.02.0010.008278%Not Available
Presyncope02.01.02.007; 24.06.02.010; 17.02.05.0090.028973%
Proctalgia07.03.02.001--
Pruritus23.03.12.0010.057945%
Pulmonary embolism24.01.06.001; 22.06.02.0010.012417%Not Available
Pulmonary hypertension24.08.03.002; 22.06.01.0010.002159%
Pulmonary infarction22.06.02.002; 24.04.09.0010.008278%Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyelonephritis acute20.01.09.002; 11.01.14.0030.008278%Not Available
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.0030.012417%Not Available
Rash maculo-papular23.03.13.0040.008278%
Rectal haemorrhage24.07.02.018; 07.12.03.0010.020695%
Renal failure20.01.03.0050.012417%Not Available
Renal tubular disorder20.05.03.004--Not Available
Respiratory disorder22.02.07.0020.016556%Not Available
Respiratory distress22.02.01.0120.008278%Not Available
Retching07.01.07.0020.008278%Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
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