Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Itraconazole
Drug ID BADD_D01217
Description One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Indications and Usage For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Marketing Status Prescription; Discontinued
ATC Code J02AC02
DrugBank ID DB01167
KEGG ID D00350
MeSH ID D017964
PubChem ID 55283
TTD Drug ID D0V4IB
NDC Product Code 12578-299; 50268-450; 53069-0450; 58032-0110; 0378-5100; 68382-697; 66577-044; 63629-8168; 60687-299; 10147-0150; 70518-3264; 50458-290; 62991-3078; 10147-1700; 71747-002; 65162-630; 67835-5043; 16729-271; 10695-064; 22568-1108; 67877-454; 31722-006; 65162-087; 46708-204; 38779-2759; 62332-204; 60592-318; 72761-019; 70771-1208; 49884-239; 70518-2872; 66039-815; 17511-114; 50458-295; 59349-0012; 13668-463; 0395-8113; 71052-301; 50546-462; 16714-743; 51552-0920; 65015-624; 51862-462
Synonyms Itraconazole | R-51211 | R 51211 | R51211 | Sporanox | Orungal
Chemical Information
Molecular Formula C35H38Cl2N8O4
CAS Registry Number 84625-61-6
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C 7=C(C=C(C=C7)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bacteriuria20.02.01.023; 11.02.01.014--Not Available
Benign prostatic hyperplasia21.04.02.0010.009282%Not Available
Bladder pain20.02.02.001--Not Available
Blister23.03.01.001; 12.01.06.0020.009282%Not Available
Blood bilirubin increased13.03.01.0080.055694%
Blood creatine phosphokinase increased13.04.01.0010.013924%
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.0020.013924%Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood pressure increased13.14.03.0050.018565%Not Available
Blood triglycerides increased13.12.03.001--Not Available
Blood urea increased13.13.01.006--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.0020.023206%Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.0010.013924%
Bronchopulmonary aspergillosis22.07.08.001; 11.03.01.0020.012107%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bursitis15.04.01.0010.009282%Not Available
Cardiac arrest02.03.04.0010.008475%
Cardiac failure02.05.01.0010.014529%
Cardiac failure acute02.05.01.0050.003632%Not Available
Cardiac failure congestive02.05.01.0020.041771%Not Available
Cardiac murmur13.14.01.0010.009282%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cellulitis23.09.01.001; 11.02.01.0010.009282%Not Available
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.002421%Not Available
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.0010.027847%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.023206%Not Available
Chills15.05.03.016; 08.01.09.0010.009282%
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