Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Itraconazole
Drug ID BADD_D01217
Description One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Indications and Usage For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Marketing Status Prescription; Discontinued
ATC Code J02AC02
DrugBank ID DB01167
KEGG ID D00350
MeSH ID D017964
PubChem ID 55283
TTD Drug ID D0V4IB
NDC Product Code 12578-299; 50268-450; 53069-0450; 58032-0110; 0378-5100; 68382-697; 66577-044; 63629-8168; 60687-299; 10147-0150; 70518-3264; 50458-290; 62991-3078; 10147-1700; 71747-002; 65162-630; 67835-5043; 16729-271; 10695-064; 22568-1108; 67877-454; 31722-006; 65162-087; 46708-204; 38779-2759; 62332-204; 60592-318; 72761-019; 70771-1208; 49884-239; 70518-2872; 66039-815; 17511-114; 50458-295; 59349-0012; 13668-463; 0395-8113; 71052-301; 50546-462; 16714-743; 51552-0920; 65015-624; 51862-462
Synonyms Itraconazole | R-51211 | R 51211 | R51211 | Sporanox | Orungal
Chemical Information
Molecular Formula C35H38Cl2N8O4
CAS Registry Number 84625-61-6
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C 7=C(C=C(C=C7)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cystitis noninfective20.03.02.001--
Self injurious behaviour19.12.01.0050.009282%Not Available
Immune reconstitution inflammatory syndrome10.02.01.043; 08.06.02.0140.009282%Not Available
Bronchial hyperreactivity22.03.01.016--Not Available
Treatment failure08.06.01.0170.009686%Not Available
Liver injury12.01.02.003; 09.01.07.0220.023206%Not Available
Oropharyngeal discomfort07.05.05.008; 22.02.05.027--Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.004--
Acute kidney injury20.01.03.0160.027847%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.064977%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.009282%Not Available
Pneumocystis jirovecii infection11.03.07.004--Not Available
Candida infection11.03.03.0210.037129%
Aspergillus infection11.03.01.0040.016950%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.007264%
Cardiac failure chronic02.05.01.0090.009282%Not Available
Faeces pale07.01.03.0050.009282%Not Available
Histoplasmosis disseminated11.03.06.0030.009282%Not Available
Hyperaldosteronism24.08.04.005; 14.05.04.006; 05.01.01.0060.037129%Not Available
Phaehyphomycosis23.09.02.015; 11.03.05.0260.009282%Not Available
Pulmonary mycosis22.07.08.013; 11.03.05.0270.003632%Not Available
Brain natriuretic peptide increased13.02.04.0110.009282%Not Available
Trichosporon infection11.03.05.0310.013924%Not Available
Acute left ventricular failure02.05.02.0050.018565%Not Available
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