Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Itraconazole
Drug ID BADD_D01217
Description One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Indications and Usage For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Marketing Status Prescription; Discontinued
ATC Code J02AC02
DrugBank ID DB01167
KEGG ID D00350
MeSH ID D017964
PubChem ID 55283
TTD Drug ID D0V4IB
NDC Product Code 12578-299; 50268-450; 53069-0450; 58032-0110; 0378-5100; 68382-697; 66577-044; 63629-8168; 60687-299; 10147-0150; 70518-3264; 50458-290; 62991-3078; 10147-1700; 71747-002; 65162-630; 67835-5043; 16729-271; 10695-064; 22568-1108; 67877-454; 31722-006; 65162-087; 46708-204; 38779-2759; 62332-204; 60592-318; 72761-019; 70771-1208; 49884-239; 70518-2872; 66039-815; 17511-114; 50458-295; 59349-0012; 13668-463; 0395-8113; 71052-301; 50546-462; 16714-743; 51552-0920; 65015-624; 51862-462
Synonyms Itraconazole | R-51211 | R 51211 | R51211 | Sporanox | Orungal
Chemical Information
Molecular Formula C35H38Cl2N8O4
CAS Registry Number 84625-61-6
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C 7=C(C=C(C=C7)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug resistance08.06.01.0050.021793%Not Available
Urine output decreased13.13.03.0010.009282%
Hepatic enzyme increased13.03.01.0190.046412%Not Available
Hot flush24.03.01.005; 08.01.03.027; 21.02.02.001--
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.01.01.0030.003632%Not Available
Connective tissue disorder15.06.01.006--Not Available
Gastrointestinal injury12.01.02.002; 07.11.01.0060.009282%Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Lung infection22.07.01.008; 11.01.09.0080.006054%
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Mucosal haemorrhage24.07.01.011; 08.01.06.0050.009282%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.032488%
Erectile dysfunction19.08.04.001; 21.03.01.007--
Pseudomonas infection11.02.12.0010.009282%Not Available
Renal injury20.01.03.015; 12.01.05.0010.009282%Not Available
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Blood disorder01.05.01.004--Not Available
Disease progression08.01.03.038--
Disease recurrence08.01.03.0500.009282%Not Available
Drug intolerance08.06.01.0130.037129%Not Available
Hepatobiliary disease09.01.08.003--Not Available
Immunosuppressant drug level increased13.17.01.0130.013924%Not Available
Urine analysis abnormal13.13.02.008--Not Available
Renal impairment20.01.03.0100.041771%Not Available
Increased bronchial secretion22.02.04.007--Not Available
Hepatic enzyme abnormal13.03.01.020--Not Available
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