Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isoniazid
Drug ID BADD_D01204
Description Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Indications and Usage For the treatment of all forms of tuberculosis in which organisms are susceptible.
Marketing Status Prescription; Discontinued
ATC Code J04AC01
DrugBank ID DB00951
KEGG ID D00346
MeSH ID D007538
PubChem ID 3767
TTD Drug ID D09XQF
NDC Product Code 71610-108; 50090-1490; 60687-553; 43063-463; 71052-611; 50090-0370; 12785-0002; 50090-0410; 0527-1109; 53002-2920; 71335-0275; 68788-9405; 71610-395; 0555-0071; 46287-009; 63187-978; 12785-0003; 66639-914; 0781-3056; 0555-0066; 70518-0096; 70518-2576; 51079-083
Synonyms Isoniazid | Isonicotinic Acid Hydrazide | Hydrazide, Isonicotinic Acid | Phthivazide | Phthivazid | Isonicotinic Acid Vanillylidenehydrazide | Acid Vanillylidenehydrazide, Isonicotinic | Vanillylidenehydrazide, Isonicotinic Acid | Ftivazide | Tubazide | Isonex
Chemical Information
Molecular Formula C6H7N3O
CAS Registry Number 54-85-3
SMILES C1=CN=CC=C1C(=O)NN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
HepatotoxicityAlbuminP02770Not Available26004706
HepatotoxicityCatalaseP04762Not Available26004706
HepatotoxicityN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
HepatotoxicityOmega-amidase NIT2Q9JHW2Not Available26004706
HepatotoxicityGlutathione peroxidase 1P04041Not Available26004706
HepatotoxicityAlanine aminotransferase 1P24298Not Available4000989; 707874; 110184
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic failure09.01.03.0020.023265%
Hepatic function abnormal09.01.02.0010.033236%Not Available
Hepatic necrosis09.01.07.0020.011633%
Hepatic steatosis14.08.04.005; 09.01.07.0030.012741%Not Available
Hepatitis09.01.07.0040.101924%Not Available
Hepatitis acute09.01.07.0050.025481%Not Available
Hepatitis B11.05.06.002; 09.01.09.0030.012741%
Hepatitis cholestatic09.01.01.0020.050962%Not Available
Hepatitis fulminant11.07.01.003; 09.01.07.0070.008309%Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.009971%Not Available
Hepatocellular injury09.01.07.0080.038222%Not Available
Hepatomegaly09.01.05.0010.031851%Not Available
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.012741%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.414068%Not Available
Human herpesvirus 6 infection11.05.02.0200.012741%Not Available
Hyperammonaemia14.10.01.001; 09.01.02.0020.012741%Not Available
Hyperbilirubinaemia09.01.01.003; 01.06.04.003; 14.11.01.0100.004985%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.012741%
Hyperglycaemia14.06.02.002; 05.06.02.0020.019111%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.0010.038222%
Hypersensitivity10.01.03.003--
Hypersensitivity vasculitis24.05.02.012; 23.06.02.005; 10.02.02.017; 01.01.04.0080.025481%Not Available
Hypertonia17.05.02.001; 15.05.04.0070.012741%Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypoglycaemia05.06.03.001; 14.06.03.0010.012741%
Hypokalaemia14.05.03.0020.025481%
Hypotension24.06.03.002--
Hypouricaemia14.09.01.0060.019111%Not Available
Immune system disorder10.02.01.0010.031851%Not Available
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