Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isoniazid
Drug ID BADD_D01204
Description Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Indications and Usage For the treatment of all forms of tuberculosis in which organisms are susceptible.
Marketing Status Prescription; Discontinued
ATC Code J04AC01
DrugBank ID DB00951
KEGG ID D00346
MeSH ID D007538
PubChem ID 3767
TTD Drug ID D09XQF
NDC Product Code 71610-108; 50090-1490; 60687-553; 43063-463; 71052-611; 50090-0370; 12785-0002; 50090-0410; 0527-1109; 53002-2920; 71335-0275; 68788-9405; 71610-395; 0555-0071; 46287-009; 63187-978; 12785-0003; 66639-914; 0781-3056; 0555-0066; 70518-0096; 70518-2576; 51079-083
Synonyms Isoniazid | Isonicotinic Acid Hydrazide | Hydrazide, Isonicotinic Acid | Phthivazide | Phthivazid | Isonicotinic Acid Vanillylidenehydrazide | Acid Vanillylidenehydrazide, Isonicotinic | Vanillylidenehydrazide, Isonicotinic Acid | Ftivazide | Tubazide | Isonex
Chemical Information
Molecular Formula C6H7N3O
CAS Registry Number 54-85-3
SMILES C1=CN=CC=C1C(=O)NN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityAlbuminP02770Not Available26004706
HepatotoxicityCatalaseP04762Not Available26004706
HepatotoxicityN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
HepatotoxicityOmega-amidase NIT2Q9JHW2Not Available26004706
HepatotoxicityGlutathione peroxidase 1P04041Not Available26004706
HepatotoxicityAlanine aminotransferase 1P24298Not Available4000989; 707874; 110184
HepatotoxicityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Drug intolerance08.06.01.0130.031851%Not Available
Psychotic disorder19.03.01.0020.012741%
Lymphocyte morphology abnormal13.01.06.0150.012741%Not Available
Renal impairment20.01.03.0100.057332%Not Available
Hepatic enzyme abnormal13.03.01.0200.012741%Not Available
Breath sounds abnormal13.15.01.0080.012741%Not Available
Liver injury12.01.02.003; 09.01.07.0220.070073%Not Available
Cholestatic liver injury09.01.07.0160.019111%Not Available
Nail atrophy23.02.05.010--Not Available
Acute kidney injury20.01.03.0160.089184%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.101370%Not Available
Substance-induced psychotic disorder19.03.01.007; 12.03.01.0530.050962%Not Available
Drug reaction with eosinophilia and systemic symptoms23.03.05.005; 10.01.01.0210.318514%Not Available
Autoimmune haemolytic anaemia01.06.01.004; 10.04.01.0050.003324%Not Available
Immune thrombocytopenic purpura01.08.01.007; 10.04.01.0080.012741%Not Available
Liver function test increased13.03.01.0440.031851%Not Available
Dermatitis exfoliative generalised10.01.01.029; 23.03.07.0020.012741%Not Available
Hilar lymphadenopathy22.09.03.005; 01.09.01.0230.012741%Not Available
IgA nephropathy20.05.01.016; 10.02.01.0630.019111%Not Available
Kussmaul respiration14.01.01.004; 22.02.01.0080.012741%Not Available
Meningitis tuberculous11.04.01.012; 17.06.10.0050.003324%Not Available
Normal newborn18.08.06.0010.012741%Not Available
Renal glycosuria20.05.03.0200.012741%Not Available
Respiratory rate increased13.15.01.0040.012741%Not Available
Limb hypoplasia congenital15.11.07.025; 03.11.07.0250.012741%Not Available
Anti-neutrophil cytoplasmic antibody positive vasculitis10.02.02.023; 24.05.02.0160.003324%Not Available
Cell death14.11.02.005; 08.03.03.0030.012741%Not Available
Histology abnormal13.18.02.0040.012741%Not Available
Primary progressive multiple sclerosis17.16.01.0050.012741%Not Available
Extrapulmonary tuberculosis11.04.01.0110.012741%Not Available
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