Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ioxaglic acid
Drug ID BADD_D01188
Description Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during angiography, arteriography, arthrography, cholangiography, urography, and computed tomography [L1889]. Ioxaglic acid has a low osmolarity and is associated with fewer side effects compared to older contrast agents [L1883].
Indications and Usage This medicinal product is for diagnostic use only in adults and children as a low-osmolality medium [L1883], [A7924].
Marketing Status Discontinued
ATC Code V08AB03
DrugBank ID DB09313
KEGG ID D01761
MeSH ID D007485
PubChem ID 3742
TTD Drug ID D0X7IT
NDC Product Code Not Available
Synonyms Ioxaglic Acid | Ioxaglate Meglumine | Meglumine, Ioxaglate | Methylglucamine Ioxaglate | Ioxaglate, Methylglucamine | Hexabrix | Ioxaglic Acid, Calcium Salt (2:1) | P-286 (Contrast Media) | P286 (Contrast Media) | Ioxaglate | Ioxaglate Sodium | Ioxaglic Acid Monosodium Salt
Chemical Information
Molecular Formula C24H21I6N5O8
CAS Registry Number 59017-64-0
SMILES CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I) C(=O)NC)I
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain08.01.08.004--
Paralysis17.01.04.004--Not Available
Paresis17.01.04.008--Not Available
Pruritus23.03.12.001--
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rash maculo-papular23.03.13.004--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sneezing22.02.05.011--
Spinal cord injury17.10.04.001; 12.01.13.002--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tenderness08.01.08.005--Not Available
Thrombophlebitis24.01.02.001--Not Available
Thrombosis24.01.01.006--Not Available
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Vasospasm24.04.02.002--Not Available
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.010--
Visual field defect17.17.01.001; 06.02.07.003--Not Available
Vomiting07.01.07.003--
Wheezing22.03.01.009--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Coronary artery insufficiency24.04.04.016; 02.02.01.008--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhage24.07.01.002--Not Available
Vasodilation procedure25.03.01.001--Not Available
Neurological symptom17.02.05.010--Not Available
Infarction24.04.02.017--Not Available
Cardiac fibrillation02.03.02.021--Not Available
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