ADReCS

Pharmaceutical Information

Drug Name	Iodixanol
Drug ID	BADD_D01178
Description	Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Indications and Usage	Iodixanol is a contrast agent during coronary angiography.
Marketing Status	approved
ATC Code	V08AB09
DrugBank ID	DB01249
KEGG ID	D01474
MeSH ID	C044834
PubChem ID	3724
TTD Drug ID	D0Y4YG
NDC Product Code	71806-222; 65219-381; 0407-2223; 65219-383; 0407-2222; 57884-0029
UNII	HW8W27HTXX
Synonyms	iodixanol \| Visipaque \| Visipaque Unique Softpac \| iodixanol-320 \| contrast media 2-5410-3

Chemical Information

Molecular Formula	C35H44I6N6O15
CAS Registry Number	92339-11-2
SMILES	CC(=O)N(CC(CN(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)C)O)C2=C(C(= C(C(=C2I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Conjunctivitis	06.04.01.002; 11.01.06.012	-	-
Contrast media reaction	12.02.05.029; 10.01.01.011	0.118082%		Not Available
Cough	22.02.03.001	0.185659%
Cyanosis	22.02.02.007; 23.06.04.005; 02.11.04.004; 24.03.01.007	0.072557%
Deafness	04.02.01.001	-	-	Not Available
Delirium	19.13.02.001	0.010670%
Depressed level of consciousness	17.02.04.002	0.014227%
Dermatitis	23.03.04.002	0.010670%		Not Available
Dermatitis allergic	10.01.03.014; 23.03.04.003	0.067577%		Not Available
Dermatitis bullous	23.03.01.002	0.017783%
Diarrhoea	07.02.01.001	-	-
Diplopia	17.17.01.005; 06.02.06.002	0.007113%		Not Available
Discomfort	08.01.08.003	0.017783%		Not Available
Disorientation	19.13.01.002; 17.02.05.015	0.007113%		Not Available
Disseminated intravascular coagulation	24.01.01.010; 01.01.02.002	-	-
Dizziness	02.11.04.006; 24.06.02.007; 17.02.05.003	0.109546%
Drug eruption	08.01.06.015; 23.03.05.001; 10.01.01.005	0.014227%		Not Available
Dry mouth	07.06.01.002	0.017783%
Dry skin	23.03.03.001	-	-
Dysgeusia	17.02.07.003; 07.14.03.001	-	-
Dyskinesia	17.01.02.006	-	-
Dyspepsia	07.01.02.001	-	-
Dysphagia	07.01.06.003	0.028454%
Dysphonia	22.12.03.006; 19.19.03.002; 17.02.08.004	0.053350%
Dysphoria	19.04.02.004	0.024897%		Not Available
Dyspnoea	02.11.05.003; 22.02.01.004	0.468061%
Dystonia	17.01.03.001	0.014227%		Not Available
Ear pain	04.03.01.003	-	-
Encephalopathy	17.13.02.001	0.010670%
Eosinophilia	01.02.04.001	0.032010%

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