Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Insulin lispro
Drug ID BADD_D01165
Description Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions.
Indications and Usage For the treatment of Type 1 or 2 diabetes mellitus. To be used in conjunction with an intermediate or long-acting insulin except when used in a continuous insulin infusion pump.
Marketing Status Prescription; Discontinued
ATC Code A10AB04; A10AC04; A10AD04
DrugBank ID DB00046
KEGG ID D04477
MeSH ID D061268
PubChem ID 16132438
TTD Drug ID D0L6JE
NDC Product Code 66733-773; 0024-5924; 70518-1389; 0110-0541; 0002-8222; 0024-5926; 0002-7712; 70518-2802; 62381-7393; 0002-7737; 0002-7752; 0024-5925; 0002-8797; 50090-1375; 0002-7714; 0002-8213; 0002-0137; 0002-1455; 0002-8233; 62381-9516; 0002-8798; 0002-1099; 0002-0535; 50090-4488; 70518-2398; 0002-7516; 0002-0121; 50090-1663; 66733-822; 0002-2499; 0002-8799; 62381-7662; 0002-7512; 70518-1388; 0002-0124; 62381-7394; 0002-6007; 0002-7510; 62381-7516; 0002-2576; 50090-5391; 0110-0571; 0002-0120; 0002-7511; 50090-4073
Synonyms Insulin Lispro | Lispro, Insulin | 28(B)-Lys-29(B)-Pro-Insulin | 28(B)-Lysine-29(B)-Prolineinsulin | Insulin, Lysyl(28B)-Prolyl(28B)- | Lispro | LYSPRO | Insulin, Lys(28B)-Pro(29B)- | Humalog Kwikpen | Kwikpen, Humalog | Humalog
Chemical Information
Molecular Formula C257H389N65O77S6
CAS Registry Number 133107-64-9
SMILES CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CS)C(=O)NC(CS)C( =O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O) NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(= O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)CN.CC(C)CC(C (=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CS)C(=O)NCC(=O)NC(CC C(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O) NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)O) NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC6=CN=CN6)NC(=O )C(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(CC7=CN=CN7)NC(=O)C(CCC(=O)N)NC(=O )C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC8=CC=CC=C8)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaphylactic reaction10.01.07.001; 24.06.03.006--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Asthenia08.01.01.001--Not Available
Blood insulin13.10.02.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cough22.02.03.001--
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diabetic retinopathy14.07.01.002; 06.10.02.002; 05.07.01.002; 24.03.07.004--Not Available
Diarrhoea07.02.01.001--
Dysmenorrhoea21.01.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Gastrointestinal pain07.01.05.005--
Glycosuria20.02.01.005--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.003--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Injury12.01.08.004--Not Available
Lipoatrophy23.07.01.001; 14.08.04.006--
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