Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Insulin (human)
Drug ID BADD_D01159
Description Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mellitus, insulin is a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.
Marketing Status Discontinued
ATC Code Not Available
DrugBank ID DB00030
KEGG ID Not Available
MeSH ID D007328
PubChem ID 118984375
TTD Drug ID D0R6CD
NDC Product Code 0002-0113; 62381-0319; 72969-034; 47918-891; 0002-0095; 0002-2510; 0002-8715; 0002-0013; 62381-0719; 0338-0126; 0002-8805; 0002-0119; 47918-902; 0002-0485; 47918-878; 0002-8824; 0002-0096; 0002-8501; 0002-9307; 62381-0509; 47918-874; 47918-880; 0002-8315; 0002-8803; 0002-2045; 0002-8215; 47918-898
Synonyms Insulin | Insulin, Regular | Regular Insulin | Soluble Insulin | Insulin, Soluble | Insulin A Chain | Sodium Insulin | Insulin, Sodium | Novolin | Iletin | Insulin B Chain | Chain, Insulin B
Chemical Information
Molecular Formula C257H383N65O77S6
CAS Registry Number 11061-68-0
SMILES CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O) NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C(NC(=O)C(NC(=O)C (NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O) N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)NC(CC(=O)N)C(=O)O)C(=O)NCC(=O)NC( CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC5=CC=CC=C5)C(=O)NC(CC6=CC=CC=C6)C(= O)NC(CC7=CC=C(C=C7)O)C(=O)NC(C(C)O)C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O) O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CNC=N2)CO)NC(= O)C(CC(C)C)NC(=O)C(CC2=CNC=N2)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC( =O)C(CC2=CC=CC=C2)N)C(=O)NC(C(=O)NC(C(=O)N1)CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CC C(=O)O)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chromosomal abnormalities and abnormal gene carriersRibosomal protein S6 kinase alpha-1Q15418T83202Not Available
HypoglycaemiaIslet amyloid polypeptideP10997T56269Not Available
HypoglycaemiaInsulinP01308T82841Not Available
HypoglycaemiaVasopressin-neurophysin 2-copeptinP01185T20975Not Available
HypoglycaemiaVasopressin V1a receptorP37288T79232Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.004--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Personality change19.05.01.006; 17.02.05.019--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Productive cough22.02.03.005--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash generalised23.03.13.002--Not Available
Refraction disorder06.02.04.004--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Retinal disorder06.08.03.005--Not Available
Retinopathy proliferative05.07.01.004; 24.03.07.010; 14.07.01.004; 06.10.02.005--Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Seizure17.12.03.001--
Serum sickness12.02.08.004; 10.01.03.004--
Shock24.06.02.002--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
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