Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Indinavir sulfate
Drug ID BADD_D01151
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indications and Usage Indinavir is an antiretroviral drug for the treatment of HIV infection.
Marketing Status Prescription; Discontinued
ATC Code J05AE02
DrugBank ID DB00224
KEGG ID D00897
MeSH ID D019469
PubChem ID 5462355
TTD Drug ID D0V7CF
NDC Product Code 0006-0573; 0006-0571
Synonyms Indinavir | MK-639 | MK 639 | MK639 | L-735 524 | L 735 524 | L735 524 | L-735,524 | L 735,524 | L735,524 | Crixivan | Indinavir Sulfate | Sulfate, Indinavir | Indinavir, Sulfate (1:1)
Chemical Information
Molecular Formula C36H49N5O8S
CAS Registry Number 157810-81-6
SMILES CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC= C5.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceLipoprotein lipaseP06858T28692Not Available
Insulin resistanceAdiponectinQ15848T15572Not Available
Insulin resistanceAP-2 complex subunit betaP63010Not AvailableNot Available
Therapeutic and nontherapeutic responsesCytochrome P450 3A4P08684T37848Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urticaria10.01.06.001; 23.04.02.001--
Vasculitis24.05.02.001; 10.02.02.006--
Vomiting07.01.07.003--
Tubulointerstitial nephritis20.05.02.002--Not Available
Fat redistribution14.08.04.002--Not Available
Leukocyturia20.02.01.014--Not Available
Body fat disorder14.08.04.012--Not Available
Haemorrhage24.07.01.002--Not Available
Paraesthesia oral07.05.03.003; 17.02.06.008--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Regurgitation07.01.07.004--Not Available
Acute kidney injury20.01.03.016--
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