Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Indinavir
Drug ID BADD_D01150
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indications and Usage Indinavir is an antiretroviral drug for the treatment of HIV infection.
Marketing Status Prescription; Discontinued
ATC Code J05AE02
DrugBank ID DB00224
KEGG ID C07051
MeSH ID D019469
PubChem ID 5362440
TTD Drug ID D0V7CF
NDC Product Code Not Available
Synonyms Indinavir | MK-639 | MK 639 | MK639 | L-735 524 | L 735 524 | L735 524 | L-735,524 | L 735,524 | L735,524 | Crixivan | Indinavir Sulfate | Sulfate, Indinavir | Indinavir, Sulfate (1:1)
Chemical Information
Molecular Formula C36H47N5O4
CAS Registry Number 150378-17-9
SMILES CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC= C5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceLipoprotein lipaseP06858T2869210566684; 10996400; 15865214; 14523274
Insulin resistanceAdiponectinQ15848T1557210566684; 10996400; 15865214; 14523274
Insulin resistanceAP-2 complex subunit betaP63010Not Available10566684; 10996400; 15865214; 14523274
Therapeutic and nontherapeutic responsesCytochrome P450 3A4P08684T378488805725; 8805726; 7489857; 8614120
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypersensitivity10.01.03.003--
Hypersensitivity vasculitis23.06.02.005; 10.02.02.017; 01.01.04.008; 24.05.02.012--Not Available
Hypertriglyceridaemia14.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Immune system disorder10.02.01.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Influenza like illness08.01.03.010--
Ingrowing nail23.02.05.011--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Insulin resistance14.06.02.003; 05.06.02.003--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Lipoatrophy14.08.04.006; 23.07.01.001--
Loss of consciousness17.02.04.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Malaise08.01.01.003--
Muscle contractions involuntary17.05.03.001; 15.05.03.008--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myositis15.05.01.001--
Nausea07.01.07.001--
Nephritis20.05.02.001--Not Available
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuralgia17.02.07.005--
Neuropathy peripheral17.09.03.003--Not Available
Neurosis19.06.01.001--Not Available
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