Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Indinavir
Drug ID BADD_D01150
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indications and Usage Indinavir is an antiretroviral drug for the treatment of HIV infection.
Marketing Status Prescription; Discontinued
ATC Code J05AE02
DrugBank ID DB00224
KEGG ID C07051
MeSH ID D019469
PubChem ID 5362440
TTD Drug ID D0V7CF
NDC Product Code Not Available
Synonyms Indinavir | MK-639 | MK 639 | MK639 | L-735 524 | L 735 524 | L735 524 | L-735,524 | L 735,524 | L735,524 | Crixivan | Indinavir Sulfate | Sulfate, Indinavir | Indinavir, Sulfate (1:1)
Chemical Information
Molecular Formula C36H47N5O4
CAS Registry Number 150378-17-9
SMILES CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC= C5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceAP-2 complex subunit betaP63010Not Available10566684; 10996400; 15865214; 14523274
Insulin resistanceLipoprotein lipaseP06858T2869210566684; 10996400; 15865214; 14523274
Insulin resistanceAdiponectinQ15848T1557210566684; 10996400; 15865214; 14523274
Therapeutic and nontherapeutic responsesCytochrome P450 3A4P08684T378488805725; 8805726; 7489857; 8614120
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Folliculitis23.09.04.007; 11.01.12.018--
Food allergy10.01.01.012--Not Available
Fungal infection11.03.05.001--Not Available
Gastritis07.08.02.001--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastroenteritis viral11.05.04.005; 07.19.03.005--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gingival bleeding24.07.02.010; 07.09.07.001--Not Available
Gingivitis11.01.04.013; 07.09.03.003--
Glossodynia07.14.02.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolytic anaemia01.06.03.002--Not Available
Headache17.14.01.001--
Hepatic cirrhosis09.01.04.001--Not Available
Hepatic failure09.01.03.002--
Hepatitis09.01.07.004--Not Available
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hydronephrosis20.01.05.001--Not Available
Hyperaemia24.03.02.002--Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperlactacidaemia14.01.01.006--Not Available
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