Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Indinavir
Drug ID BADD_D01150
Description A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem]
Indications and Usage Indinavir is an antiretroviral drug for the treatment of HIV infection.
Marketing Status Prescription; Discontinued
ATC Code J05AE02
DrugBank ID DB00224
KEGG ID C07051
MeSH ID D019469
PubChem ID 5362440
TTD Drug ID D0V7CF
NDC Product Code Not Available
Synonyms Indinavir | MK-639 | MK 639 | MK639 | L-735 524 | L 735 524 | L735 524 | L-735,524 | L 735,524 | L735,524 | Crixivan | Indinavir Sulfate | Sulfate, Indinavir | Indinavir, Sulfate (1:1)
Chemical Information
Molecular Formula C36H47N5O4
CAS Registry Number 150378-17-9
SMILES CC(C)(C)NC(=O)C1CN(CCN1CC(CC(CC2=CC=CC=C2)C(=O)NC3C(CC4=CC=CC=C34)O)O)CC5=CN=CC= C5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Insulin resistanceAP-2 complex subunit betaP63010Not Available10566684; 10996400; 15865214; 14523274
Insulin resistanceLipoprotein lipaseP06858T2869210566684; 10996400; 15865214; 14523274
Insulin resistanceAdiponectinQ15848T1557210566684; 10996400; 15865214; 14523274
Therapeutic and nontherapeutic responsesCytochrome P450 3A4P08684T378488805725; 8805726; 7489857; 8614120
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cerebrovascular disorder24.03.05.002; 17.08.02.002--Not Available
Cheilitis23.03.03.025; 07.05.01.001--
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholecystitis09.03.01.001--
Cholestasis09.01.01.001--Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Crystalluria20.02.01.003--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysaesthesia17.02.06.003--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Dysuria20.02.02.002--
Eructation07.01.02.003--
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flank pain20.02.03.006; 15.03.04.003; 08.01.08.007--
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