Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Imiquimod
Drug ID BADD_D01142
Description Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Indications and Usage For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above.
Marketing Status Prescription; Discontinued
ATC Code D06BB10
DrugBank ID DB00724
KEGG ID D02500
MeSH ID D000077271
PubChem ID 57469
TTD Drug ID D06CTE
NDC Product Code 22365-121; 51927-0168; 66039-829; 0395-8244; 0093-3133; 63629-8818; 64552-4008; 62147-0087; 51672-4145; 99207-270; 62350-0077; 99207-276; 68462-536; 62147-0072; 45802-368; 68682-272; 99207-260; 72189-084; 71052-160; 99207-271; 0168-0432; 51552-1538; 58175-0397; 11517-270; 72643-006; 11517-275; 51927-4898; 51672-4174; 11517-262
Synonyms Imiquimod | 1-Isobutyl-1H-imidazo(4,5-c)quinolin-4-amine | S 26308 | S-26308 | R 837 | R-837 | R837 | Zyclara | Aldara
Chemical Information
Molecular Formula C14H16N4
CAS Registry Number 99011-02-6
SMILES CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema14.05.06.010; 08.01.07.006--Not Available
Otitis media11.01.05.004; 04.05.01.001--
Pain08.01.08.0040.009269%
Pain in extremity15.03.04.0100.003476%
Pain of skin23.03.03.0030.002317%
Palpitations02.01.02.003--
Pancytopenia01.03.03.003--Not Available
Papule23.03.03.0380.002317%Not Available
Paraesthesia17.02.06.005--
Paresis17.01.04.008--Not Available
Pemphigus23.03.01.005; 10.04.02.0030.005793%Not Available
Penis disorder21.12.01.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Platelet count13.01.04.011--Not Available
Platelet count decreased13.01.04.001--
Pleural effusion22.05.02.0020.003476%
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pregnancy18.08.02.004--Not Available
Procedural site reaction12.02.05.002--Not Available
Proctalgia07.03.02.001--
Proteinuria20.02.01.011--
Pruritus23.03.12.0010.010427%
Psoriasis23.03.14.002; 10.02.01.0360.005793%Not Available
Pulmonary congestion22.01.03.002; 02.05.02.002; 24.03.08.001--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.004634%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Punctate keratitis06.04.02.0030.003476%Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.003--
Pyrexia08.05.02.0030.012745%
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