Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oral pain07.05.03.0020.000556%
Osteoporosis15.02.03.002; 14.04.04.0020.000556%
Ovarian cancer16.12.04.001; 21.11.01.0030.000097%Not Available
Oxygen saturation decreased13.02.01.0040.002968%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.003339%
Pain in jaw15.02.01.0030.000742%Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.000371%Not Available
Palpitations02.01.02.0030.001669%
Paraesthesia17.02.06.005--
Pericardial effusion02.06.01.0020.000556%
Platelet count decreased13.01.04.001--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.0030.007049%Not Available
Premature baby18.04.02.0010.001484%Not Available
Premature delivery18.07.01.006--
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.007--
Productive cough22.02.03.0050.001855%
Pruritus23.03.12.001--
Pulmonary arterial pressure increased13.14.03.0250.000742%Not Available
Pulmonary congestion24.03.08.001; 22.01.03.002; 02.05.02.0020.000145%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary fibrosis22.01.02.0060.000290%
Pulmonary haemorrhage24.07.01.016; 22.02.04.0030.000097%
Pulmonary hypertension24.08.03.002; 22.06.01.0010.003242%
Pulmonary oedema22.01.03.003; 02.05.02.0030.004266%
Pulmonary thrombosis22.06.02.003; 24.01.06.0020.000371%Not Available
Pulmonary veno-occlusive disease24.01.06.008; 22.06.03.0030.000097%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
The 7th Page    First    Pre   7 8 9 10 11    Next   Last    Total 11 Pages