Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status approved; investigational
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 66215-303; 40016-013; 82231-109; 54893-0017; 66215-302
UNII JED5K35YGL
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypotension24.06.03.0020.001127%
Hypoxia22.02.02.0030.000452%
Immune system disorder10.02.01.001--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Intestinal obstruction07.13.01.0020.000164%Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000164%Not Available
Laboratory test abnormal13.18.01.001--Not Available
Laryngeal pain22.12.03.010--
Loss of consciousness17.02.04.0040.000740%Not Available
Lung disorder22.02.07.0010.000740%Not Available
Mouth haemorrhage24.07.02.014; 07.05.02.0010.000288%
Muscle spasms15.05.03.004--
Myocardial infarction24.04.04.009; 02.02.02.0070.000987%
Nasal congestion22.04.04.0010.000765%
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Oedema14.05.06.010; 08.01.07.0060.000617%Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.0070.001727%
Oral pain07.05.05.0340.000123%
Osteoporosis15.02.03.002; 14.04.04.0020.000123%
Ovarian cancer21.11.01.003; 16.12.04.0010.000082%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.000962%
Pain in jaw15.02.01.0030.000263%Not Available
Palpitations02.11.04.0120.000452%
Pericardial effusion02.06.01.0020.000123%
Pleural effusion22.05.02.0020.000288%
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumothorax22.05.02.0030.000082%
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