Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Emphysema22.01.02.0020.000097%Not Available
Epistaxis22.04.03.001; 24.07.01.0050.002782%
Erythema23.03.06.001--Not Available
Eye disorder06.08.03.0010.000371%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.000371%Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.0030.000556%Not Available
Facial pain08.01.08.0120.000556%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.002411%Not Available
Flank pain15.03.04.003; 08.01.08.007; 20.02.03.0060.000371%
Fluid overload14.05.06.001; 02.05.04.0040.000097%Not Available
Fluid retention20.01.02.003; 14.05.06.0020.001065%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.001298%
Gait disturbance17.02.05.016; 08.01.02.0020.002040%
Gamma-glutamyltransferase increased13.03.01.011--
Gastric haemorrhage24.07.02.007; 07.12.01.0010.000371%
Gastric ulcer07.04.03.0020.000556%
Gastritis07.08.02.0010.000371%
Gastroenteritis07.19.03.001; 11.01.07.0040.000371%Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised oedema14.05.06.007; 08.01.07.0040.000242%
Gingival bleeding07.09.07.001; 24.07.02.010--Not Available
Glaucoma06.03.01.0020.000556%
Glossitis07.14.01.001--Not Available
Glossodynia07.14.02.001--Not Available
Gout15.01.06.001; 14.09.01.0010.000371%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.001484%Not Available
Haematochezia24.07.02.012; 07.12.02.0030.000742%Not Available
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