Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood disorder01.05.01.004--Not Available
Immunodeficiency10.03.02.0020.000371%Not Available
Disease progression08.01.03.0380.001790%
Drug intolerance08.06.01.013--Not Available
Obstructive airways disorder22.03.01.0110.000371%Not Available
Investigation13.18.01.0040.000742%Not Available
Renal impairment20.01.03.010--Not Available
Respiratory tract infection22.07.07.001; 11.01.08.0170.000927%Not Available
Unevaluable event08.01.03.0510.001484%Not Available
Poor quality sleep19.02.05.005; 17.15.04.0020.000742%Not Available
Cholecystitis infective11.01.18.002; 09.03.01.0060.000371%
Coagulation test abnormal13.01.02.0180.000371%Not Available
Chronic kidney disease20.01.03.017--
Procedural pain12.02.05.007; 08.01.08.0090.000556%Not Available
Pulmonary arterial hypertension24.08.03.003; 22.06.01.0020.003775%Not Available
Low birth weight baby18.04.02.0030.001298%Not Available
Brain injury19.07.03.007; 17.11.01.0030.000242%Not Available
Oropharyngeal discomfort22.02.05.027; 07.05.05.0080.000742%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.001298%
Acute kidney injury20.01.03.016--
Hepatic cancer16.07.02.004; 09.04.02.0080.000145%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000242%
Catheterisation cardiac13.14.07.0030.001113%Not Available
Colonoscopy13.05.05.0040.000371%Not Available
Concomitant disease aggravated08.01.03.0630.000242%Not Available
Nosocomial infection11.07.02.0060.000194%Not Available
Terminal state08.01.03.0790.000097%Not Available
Right-to-left cardiac shunt22.06.01.008; 03.07.10.004; 24.08.03.0080.000097%Not Available
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