Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Post procedural haemorrhage24.07.01.014; 12.02.05.0040.000097%
Cardiopulmonary failure22.02.06.004; 02.05.01.0040.000194%Not Available
Respiratory tract congestion22.02.07.0030.000371%Not Available
Lymphatic disorder01.09.01.003--Not Available
Nasal discomfort22.02.05.0200.000371%Not Available
Pruritus generalised23.03.12.0030.000556%Not Available
Organ failure08.01.03.0410.000194%Not Available
Haemorrhage24.07.01.002--Not Available
Staphylococcal sepsis11.02.05.0030.000097%Not Available
Gastric disorder07.11.01.0030.000556%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000194%Not Available
Vasodilation procedure25.03.01.001--Not Available
Intestinal haemorrhage24.07.02.031; 07.12.03.0050.000927%Not Available
Angiopathy24.03.02.007--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Urine output decreased13.13.03.0010.000927%
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.001--
Blood test abnormal13.18.01.0030.000371%Not Available
Cardiac disorder02.01.01.0030.000532%Not Available
Connective tissue disorder15.06.01.006--Not Available
Embolism24.01.01.0090.000097%
Infarction24.04.02.0170.000145%Not Available
Inflammation08.01.05.0070.001113%Not Available
Lung infection22.07.01.008; 11.01.09.0080.000194%
Malnutrition14.03.02.0040.000371%Not Available
Mediastinal disorder22.09.03.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal function test abnormal13.13.01.0120.000556%Not Available
Respiratory fume inhalation disorder12.03.02.003; 22.02.07.0090.000371%Not Available
Ill-defined disorder08.01.03.0490.000371%Not Available
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