Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloperidone
Drug ID BADD_D01134
Description Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Indications and Usage Treatment of acute schizophrenia.
Marketing Status Prescription
ATC Code N05AX14
DrugBank ID DB04946
KEGG ID D02666
MeSH ID C081732
PubChem ID 71360
TTD Drug ID D0M8VE
NDC Product Code 51672-4178; 51672-4181; 43068-112; 43068-108; 43068-902; 43068-106; 51672-4183; 66499-0042; 46016-1332; 43068-104; 66022-0115; 63285-756; 43068-101; 50379-0006; 63285-755; 43068-901; 43068-903; 66499-0067; 51672-4180; 51672-4213; 43068-102; 51672-4179; 51672-4182; 51672-4184; 43068-110; 43068-113
Synonyms iloperidone | Fanapt | HP 873 | HP-873 | Zomaril
Chemical Information
Molecular Formula C24H27FN2O4
CAS Registry Number 133454-47-4
SMILES CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Menstruation irregular21.01.01.005; 05.05.01.008--
Metrorrhagia21.01.01.006--Not Available
Mood swings19.04.03.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle rigidity17.05.02.005; 15.05.04.0010.000602%Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Nasal congestion22.04.04.0010.000903%
Nasal dryness22.04.03.002--Not Available
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Neutrophil count increased13.01.06.011--Not Available
Nystagmus06.05.02.006; 17.02.02.006--
Obsessive-compulsive disorder19.06.05.002--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral02.05.04.007; 14.05.06.011; 08.01.07.0070.000903%
Orthostatic hypotension24.06.03.004; 17.05.01.0200.000602%Not Available
Palpitations02.01.02.003--
Panic attack19.06.04.001--Not Available
Paraesthesia17.02.06.005--
Paranoia19.05.01.005--Not Available
Parkinsonism17.01.05.003--Not Available
Pollakiuria20.02.02.007--
Polydipsia psychogenic19.24.01.004; 14.05.02.002--Not Available
Priapism21.03.01.0050.001505%Not Available
Prostatitis21.09.01.001--Not Available
Psychomotor hyperactivity17.01.02.011; 19.11.02.003--Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.000157%Not Available
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