Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Idarubicin hydrochloride
Drug ID BADD_D01128
Description An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Indications and Usage For the treatment of acute myeloid leukemia (AML) in adults. This includes French-American-British (FAB) classifications M1 through M7.
Marketing Status Prescription; Discontinued
ATC Code L01DB06
DrugBank ID DB01177
KEGG ID D01747
MeSH ID D015255
PubChem ID 636362
TTD Drug ID D01XDL
NDC Product Code 0143-9217; 0143-9306; 0143-9218; 0703-4154; 0013-2576; 0143-9219; 0703-4155; 58623-0027; 77391-003; 0703-4156; 27831-003; 17337-0098; 0013-2586; 0143-9307; 0143-9308; 0013-2596
Synonyms Idarubicin | 4-Desmethoxydaunorubicin | 4 Desmethoxydaunorubicin | 4-Demethoxydaunorubicin | 4 Demethoxydaunorubicin | IMI-30 | IMI 30 | IMI30 | NSC-256439 | NSC 256439 | NSC256439 | Idarubicin Hydrochloride | Hydrochloride, Idarubicin
Chemical Information
Molecular Formula C26H28ClNO9
CAS Registry Number 57852-57-0
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash23.03.13.001--Not Available
Rash generalised23.03.13.002--Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Mental status changes19.07.01.001--Not Available
Dermatosis23.03.03.017--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Haemorrhage24.07.01.002--Not Available
Haematology test abnormal13.01.03.002--Not Available
Cardiac disorder02.01.01.003--Not Available
Renal impairment20.01.03.010--Not Available
Bone marrow failure01.03.03.005--
Myocardial depression02.04.02.015--Not Available
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