Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ibuprofen lysine
Drug ID BADD_D01121
Description Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.[A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.[A39076] On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.[A39194]
Indications and Usage Not Available
Marketing Status Prescription; OTC; Discontinued
ATC Code C01EB16; G02CC01; M01AE01; M02AA13; R02AX02
DrugBank ID DB01050
KEGG ID D06606
MeSH ID D007052
PubChem ID 9841440
NDC Product Code 55292-122; 39822-1030; 66993-490; 46438-0003
Synonyms Ibuprofen | alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid | Ibumetin | Ibuprofen, (+-)-Isomer | Ibuprofen, (R)-Isomer | Ibuprofen, (S)-Isomer | Ibuprofen, Aluminum Salt | Ibuprofen, Calcium Salt | Ibuprofen, Copper (2+) Salt | Ibuprofen, Magnesium Salt | Ibuprofen, Potassium Salt | Ibuprofen, Sodium Salt | Ibuprofen, Zinc Salt | Ibuprofen-Zinc | Ibuprofen Zinc | Motrin | Nuprin | Rufen | Salprofen | Trauma-Dolgit Gel | Trauma Dolgit Gel | Brufen
Chemical Information
Molecular Formula C19H32N2O4
CAS Registry Number 57469-77-9
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Drug resistanceArylamine N-acetyltransferase 2P11245Not AvailableNot Available
Haemorrhagic infarctionMyeloperoxidaseP05164T23471Not Available
Ventricular fibrillationMyeloperoxidaseP05164T23471Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Adrenal insufficiency14.11.01.004;
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Cardiac failure02.05.01.001--
Cholestasis09.01.01.001--Not Available
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal perforation07.04.04.001--Not Available
Infection11.01.08.002--Not Available
Inguinal hernia07.16.02.001--Not Available
Injection site reaction08.02.03.014;
Intraventricular haemorrhage24.07.04.008; Available
Jaundice23.03.03.030;; Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; Available
Oliguria20.01.03.004--Not Available
Renal disorder20.01.02.002--Not Available
Renal failure20.01.03.005--Not Available
Respiratory failure22.02.06.002;
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