Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hyoscyamine
Drug ID BADD_D01114
Description Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553] Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
Indications and Usage For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
Marketing Status Not Available
ATC Code A03BA03
DrugBank ID DB00424
KEGG ID D00147
MeSH ID D064692
PubChem ID 154417
TTD Drug ID D0RD5W
NDC Product Code Not Available
Synonyms Hyoscyamine | Atropine, 3(S)-endo-Isomer | Cytospaz | Hyoscyamine Sulfate Anhydrous | Hyoscyamine Hydrochloride | Hyoscyamine Sulfate | Atropine Sulfate, 3(S)-endo-Isomer | Anaspaz | Hyoscyamine Hydrobromide
Chemical Information
Molecular Formula C17H23NO3
CAS Registry Number 101-31-5
SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Headache17.14.01.0010.001149%
Heart rate increased13.14.04.0020.001724%Not Available
Heart rate irregular13.14.04.0030.001724%Not Available
Hyperaemia24.03.02.002--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypohidrosis23.02.03.005; 08.01.03.029--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Intraocular pressure increased13.07.04.002--Not Available
Loss of consciousness17.02.04.0040.001149%Not Available
Malaise08.01.01.0030.001149%
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nausea07.01.07.0010.001149%
Nervousness19.06.02.003--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.0040.001149%
Palpitations02.01.02.003--
Panic attack19.06.04.0010.001149%Not Available
Rash23.03.13.001--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder17.02.08.003; 22.02.05.034; 19.19.02.0020.001149%Not Available
Strangury20.02.02.017--Not Available
Suppressed lactation21.05.02.003; 18.06.02.001--Not Available
Swelling08.01.03.015--Not Available
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