Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hyoscyamine
Drug ID BADD_D01114
Description Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553] Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
Indications and Usage For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
Marketing Status Not Available
ATC Code A03BA03
DrugBank ID DB00424
KEGG ID D00147
MeSH ID D064692
PubChem ID 154417
TTD Drug ID D0RD5W
NDC Product Code Not Available
Synonyms Hyoscyamine | Atropine, 3(S)-endo-Isomer | Cytospaz | Hyoscyamine Sulfate Anhydrous | Hyoscyamine Hydrochloride | Hyoscyamine Sulfate | Atropine Sulfate, 3(S)-endo-Isomer | Anaspaz | Hyoscyamine Hydrobromide
Chemical Information
Molecular Formula C17H23NO3
CAS Registry Number 101-31-5
SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.002874%
Accommodation disorder06.02.04.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Agitation19.06.02.001; 17.02.05.012--
Amnesia19.20.01.001; 17.03.02.0010.001149%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angle closure glaucoma06.03.01.001--Not Available
Anxiety19.06.02.0020.001724%
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Body temperature increased13.15.01.001--Not Available
Clumsiness17.01.02.005--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cycloplegia17.17.02.003; 06.05.03.002--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.003448%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.003448%
Dry eye06.08.02.001--
Dry mouth07.06.01.0020.004023%
Dysarthria17.02.08.001; 19.19.03.001--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysuria20.02.02.0020.001724%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.0090.001149%Not Available
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