ADReCS

Pharmaceutical Information

Drug Name	Hydroxyurea
Drug ID	BADD_D01110
Description	An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage	For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status	approved
ATC Code	L01XX05
DrugBank ID	DB01005
KEGG ID	D00341
MeSH ID	D006918
PubChem ID	3657
TTD Drug ID	D07CWD
NDC Product Code	0904-6939; 35369-0006; 49452-3650; 55154-7143; 61269-403; 68084-284; 70518-3615; 51927-0072; 0555-0882; 55154-3554; 69315-164; 38779-1354; 42291-321; 71770-105; 49884-724; 17337-0023; 0003-6335; 0003-6337; 60429-265; 61269-835; 70518-0916; 55512-0003; 61269-402; 71770-120; 0003-0830; 51552-0851; 62049-135; 0003-6336; 61269-404; 10135-702; 71052-323; 17337-0022
UNII	X6Q56QN5QC
Synonyms	Hydroxyurea \| Hydroxycarbamid \| Oncocarbide \| Hydrea

Chemical Information

Molecular Formula	CH4N2O2
CAS Registry Number	127-07-1
SMILES	C(=O)(N)NO
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Skin lesion	23.03.03.010	0.000112%		Not Available
Skin necrosis	23.03.03.011	0.000224%		Not Available
Skin ulcer	24.04.03.007; 23.07.03.003	0.002295%
Somnolence	19.02.05.003; 17.02.04.006	-	-
Speech disorder	22.12.03.027; 19.19.02.002; 17.02.08.003	0.000168%		Not Available
Spermatogenesis abnormal	21.03.03.002	0.000336%		Not Available
Spleen disorder	01.09.02.003	0.000112%		Not Available
Splenic infarction	24.04.08.024; 01.09.02.004	0.000168%		Not Available
Splenomegaly	01.09.02.001	0.001869%		Not Available
Squamous cell carcinoma	16.16.01.002	0.001343%		Not Available
Squamous cell carcinoma of skin	23.08.02.005; 16.03.02.005	0.001119%		Not Available
Stillbirth	18.01.02.002; 08.04.01.006	0.000112%		Not Available
Stomatitis	07.05.06.005	0.000660%
Subarachnoid haemorrhage	17.08.01.010; 24.07.04.004; 12.01.10.011	0.000112%		Not Available
Systemic lupus erythematosus	10.04.03.004; 23.03.02.006; 15.06.02.003	-	-	Not Available
Tenderness	08.01.08.005	-	-	Not Available
Testicular disorder	21.13.01.002	0.000112%
Therapeutic response decreased	08.06.01.016	0.000280%		Not Available
Thrombocytopenia	01.08.01.002	0.002183%		Not Available
Thrombocytosis	01.08.02.001	0.000470%		Not Available
Tongue neoplasm malignant stage unspecified	16.13.07.003; 07.21.07.003	0.000504%		Not Available
Tumour lysis syndrome	16.32.03.002; 14.05.01.004	0.000448%
Ulcer	08.03.06.001	0.000548%		Not Available
Upper gastrointestinal haemorrhage	24.07.02.024; 07.12.02.006	0.000168%
Ureteric obstruction	20.06.01.005	-	-	Not Available
Urinary incontinence	20.02.02.010; 17.05.01.008	0.000112%
Uterine cancer	21.07.02.003; 16.12.05.001	0.000168%		Not Available
Vasculitis	10.02.02.006; 24.12.04.027	0.000168%
Ventricular tachycardia	02.03.04.010	0.000112%
Vomiting	07.01.07.003	-	-

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