Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status Prescription; Discontinued
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 70518-0916; 0904-6939; 51927-0072; 49452-3650; 0003-6337; 60429-265; 55154-7143; 0003-0830; 10135-702; 71770-120; 49884-724; 55512-0003; 68084-284; 51552-0851; 17337-0022; 0003-6336; 35369-0006; 0555-0882; 0003-6335; 42291-321; 51927-2655; 71052-323; 69315-164; 17337-0023; 71770-105
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chronic myeloid leukaemiaTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
HepatomegalyTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastric cancer16.13.03.001; 07.21.02.0010.000556%Not Available
Gastric haemorrhage24.07.02.007; 07.12.01.0010.001066%
Gastric ulcer07.04.03.0020.001332%
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gout15.01.06.001; 14.09.01.0010.000533%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000533%Not Available
Haematocrit decreased13.01.05.0010.000799%Not Available
Haematocrit increased13.01.05.0020.000533%Not Available
Haematoma24.07.01.0010.001332%
Haematuria24.07.01.047; 20.02.01.0060.000799%
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.0030.006394%Not Available
Haemoglobin increased13.01.05.0040.000533%
Haemolysis01.06.04.0020.000139%
Haemolytic anaemia01.06.03.0020.001865%Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hemiparesis17.01.04.0010.000208%
Hemiplegia17.01.04.0020.000208%Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.0010.003197%Not Available
Hepatitis09.01.07.0040.000533%Not Available
Hepatitis B11.05.06.002; 09.01.09.0030.001066%
Hepatosplenomegaly09.01.05.002; 01.09.03.0010.000139%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.0090.000533%Not Available
Hernia08.01.04.0010.001332%Not Available
Herpes simplex23.09.03.001; 11.05.02.0010.000139%Not Available
Herpes zoster11.05.02.003; 23.09.03.0020.001865%
Hip fracture15.08.03.001; 12.04.01.0010.000799%
The 5th Page    First    Pre   5 6 7 8 9    Next   Last    Total 14 Pages