Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyethyl starch
Drug ID BADD_D01105
Description Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
Indications and Usage An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
Marketing Status Not Available
ATC Code B05AA07
DrugBank ID DB09106
KEGG ID D03335
MeSH ID D006895
PubChem ID 16213095
TTD Drug ID D0M5OG
NDC Product Code Not Available
Synonyms Hydroxyethyl Starch Derivatives | Derivatives, Hydroxyethyl Starch | Starch Derivatives, Hydroxyethyl | Hydroxyethylated Starches | Starches, Hydroxyethylated | Starches, 2-Hydroxyethyl | 2-Hydroxyethyl Starches | Starches, 2 Hydroxyethyl | Hemohes | Elohes | Hespan | Hetastarch | Pentafraction | Pentaspan | Pentastarch | Plasmasteril | HAES-steril | Hydroxyethyl Starch 130-0.4 | Hydroxyethyl Starch 130 0.4 | Hydroxyethyl Starch (130 KD-0.4 Substitution)
Chemical Information
Molecular Formula C22H44O17
CAS Registry Number 9005-27-0
SMILES C(COCC1C(C(C(C(O1)OCCO)OCCO)OCCO)OCCO)O.C(C1C(C(C(C(O1)O)O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Blood donor26.01.04.001--Not Available
Circulatory collapse24.06.02.001--Not Available
Coagulopathy01.01.02.001--Not Available
Death08.04.01.001--
Haematocrit decreased13.01.05.001--Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Impaired healing08.03.02.001--Not Available
Pancreatitis07.18.01.001--
Prothrombin level increased13.01.02.011--Not Available
Pruritus23.03.12.001--
Red blood cell count decreased13.01.05.007--Not Available
Sepsis11.01.11.003--
Shock24.06.02.002--Not Available
Wound haemorrhage12.01.08.017; 24.07.01.029--Not Available
Dilutional coagulopathy12.01.08.031; 01.01.02.011--Not Available
Anti factor VIII antibody test13.01.02.035--Not Available
Von Willebrand's factor activity abnormal13.01.02.042--Not Available
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