ADReCS

Pharmaceutical Information

Drug Name	Hydroxychloroquine
Drug ID	BADD_D01103
Description	Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].[L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus.[L8072] Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely.[L8072] It was developed during World War II as a derivative of [quinacrine] with less severe side effects.[A183092] Chloroquine and hydroxychloroquine are both being investigated for the treatment of SARS-CoV-2.[A192132] The FDA emergency use authorization for hydroxychloroquine and [chloroquine] in the treatment of COVID-19 was revoked on 15 June 2020.[L14312] Hydroxychloroquine was granted FDA approval on 18 April 1955.[L8072] A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.[A192546]
Indications and Usage	Hydroxychloroquine is indicated for the prophylaxis of malaria where chloroquine resistance is not reported, treatment of uncomplicated malaria (caused by _P. falciparum_, _P. malariae_, _P. ovale_, or _P. vivax_), chronic discoid lupus erythematosus, systemic lupus erythematosus, acute rheumatoid arthritis, and chronic rheumatoid arthritis.[L8072]
Marketing Status	approved
ATC Code	P01BA02
DrugBank ID	DB01611
KEGG ID	D08050
MeSH ID	D006886
PubChem ID	3652
TTD Drug ID	D0OJ4L
NDC Product Code	Not Available
UNII	4QWG6N8QKH
Synonyms	Hydroxychloroquine \| Oxychlorochin \| Oxychloroquine \| Hydroxychlorochin \| Plaquenil \| Hydroxychloroquine Sulfate \| Hydroxychloroquine Sulfate (1:1) Salt

Chemical Information

Molecular Formula	C18H26ClN3O
CAS Registry Number	118-42-3
SMILES	CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Cardiotoxicity	02.11.01.009; 12.03.01.007	0.007438%		Not Available
Acute generalised exanthematous pustulosis	11.07.01.018; 10.01.01.034; 23.03.10.002; 12.03.01.005	0.013388%		Not Available
Deafness unilateral	04.02.01.011	0.007438%		Not Available
Hypoacusis	04.02.01.006	-	-
Retinal toxicity	12.03.01.036; 06.09.03.013	0.005578%		Not Available
Peripheral swelling	08.01.03.053; 02.05.04.015	-	-	Not Available
Tachyarrhythmia	02.03.02.008	0.004648%		Not Available
Left ventricular dysfunction	02.04.02.011	0.002789%
Left ventricular hypertrophy	02.04.02.014	0.003719%		Not Available
Balance disorder	08.01.03.081; 17.02.02.007	0.005020%		Not Available
Intervertebral disc protrusion	15.10.01.004	0.001859%		Not Available
Lupus-like syndrome	10.04.03.003; 23.03.02.004; 15.06.02.004	0.001859%		Not Available
Contusion	12.01.06.001; 15.03.05.007; 24.07.06.001; 23.03.11.002	-	-
Tonic clonic movements	17.12.03.006	0.001859%		Not Available
Vascular calcification	24.03.02.013	0.001859%		Not Available
Diastolic dysfunction	02.04.02.022	0.001859%		Not Available
Detachment of retinal pigment epithelium	06.09.03.011	0.004648%		Not Available
Foetor hepaticus	07.01.06.026; 09.01.05.006	-	-	Not Available
Deafness bilateral	04.02.01.007	0.009297%		Not Available
Eosinophilic pneumonia acute	22.01.01.008; 01.02.04.004	0.001859%		Not Available
Musculoskeletal stiffness	15.03.05.027	-	-	Not Available
Nodule	08.03.05.002	-	-	Not Available
Affect lability	19.04.01.001	-	-	Not Available
Skin burning sensation	23.03.03.021; 17.02.06.009	0.005020%		Not Available
Haemorrhage	24.07.01.002	-	-	Not Available
Cutaneous lupus erythematosus	23.03.02.008; 15.06.02.007; 10.04.03.007	0.001859%		Not Available
Paraesthesia oral	07.05.05.035; 17.02.06.008	-	-	Not Available
Breast cancer female	21.05.01.011; 16.10.01.004	-	-	Not Available
Cognitive disorder	17.03.03.003; 19.21.02.001	-	-
Toxic skin eruption	12.03.01.073; 23.03.05.003; 10.01.01.008	0.022313%		Not Available

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