Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroquinone
Drug ID BADD_D01097
Description Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.
Indications and Usage Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.
Marketing Status Not Available
ATC Code D11AX11
DrugBank ID DB09526
KEGG ID D00073
MeSH ID C031927
PubChem ID 785
TTD Drug ID D03UOT
NDC Product Code 42851-037; 42851-038; 24689-101; 10135-724; 73428-1001; 71399-0400; 68723-142; 62032-100; 71177-162; 50268-343; 62032-122; 71221-995; 42851-184; 0395-8127; 78863-1050; 72251-005; 76420-160; 42851-039; 62032-105; 72364-346; 62991-1196; 51927-1124; 50066-055; 68634-006; 38779-0075; 24979-141; 63742-025; 42192-151; 30815-0040; 76038-090; 11410-045; 60767-8992; 68723-143; 72957-004; 71177-008; 51552-0066; 71804-231; 42582-700; 62032-101; 51927-0035; 71421-501; 42851-035; 50218-009; 42851-036; 68062-9105; 62032-106; 69367-174; 64760-701; 81097-107; 68062-9104; 49452-3620
Synonyms hydroquinone | p-benzenediol | 1,4-dihydroxybenzene | 1,4-benzenediol | beta-quinol | Hidroquin | Hidroquinona Isdin | hydroquinone, copper (1+) salt | hydroquinone, lead (2+) salt (2:1) | hydroquinone, monocopper (2+) salt | Licostrata | Lustra | Melanasa | Melanex | Melpaque | Melquin | Neostrata HQ | Phiaquin | Artra | Eldopaque | Eldoquin | Ultraquin | Solaquin | Esoterica | Hidroquilaude
Chemical Information
Molecular Formula C6H6O2
CAS Registry Number 123-31-9
SMILES C1=CC(=CC=C1O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Erythema23.03.06.001--Not Available
Hypersensitivity10.01.03.003--
Pain08.01.08.004--
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