Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroflumethiazide
Drug ID BADD_D01093
Description A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Indications and Usage Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.
Marketing Status Discontinued
ATC Code C03AA02
DrugBank ID DB00774
KEGG ID D00654
MeSH ID D006857
PubChem ID 3647
TTD Drug ID D00WAM
NDC Product Code Not Available
Synonyms Hydroflumethiazide | Trifluoromethylhydrothiazide | Diucardin
Chemical Information
Molecular Formula C8H8F3N3O4S2
CAS Registry Number 135-09-1
SMILES C1NC2=C(C=C(C(=C2)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Aplastic anaemia01.03.03.002--Not Available
Asthenia08.01.01.001--Not Available
Blood uric acid increased13.02.04.001--Not Available
Constipation07.02.02.001--
Cutaneous vasculitis24.05.02.004; 23.06.02.001; 10.02.02.003--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug abuse19.07.02.010--Not Available
Glycosuria20.02.01.005--
Headache17.14.01.001--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypersensitivity10.01.03.003--
Hyperuricaemia14.09.01.003--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Leukopenia01.02.02.001--Not Available
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pancreatitis07.18.01.001--
Paraesthesia17.02.06.005--
Photosensitivity reaction23.03.09.003--
Purpura23.06.01.004; 01.01.04.003; 24.07.06.005--
Rash23.03.13.001--Not Available
Restlessness19.11.02.002; 17.02.05.021--
Thrombocytopenia01.08.01.002--Not Available
Urticaria23.04.02.001; 10.01.06.001--
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