Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone sodium succinate
Drug ID BADD_D01091
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00978
MeSH ID D006854
PubChem ID 23694214
TTD Drug ID D0KR5B
NDC Product Code 55154-3942; 0009-0005; 0009-0016; 22552-0007; 64958-0020; 0009-0011; 0009-0825; 0009-0013
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C25H33NaO8
CAS Registry Number 125-04-2
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T22658Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial rupture12.01.11.002; 02.04.02.002--Not Available
Myopathy15.05.05.001--Not Available
Nausea07.01.07.001--
Neuritis17.09.03.001--Not Available
Neuropathic arthropathy15.01.01.007; 17.09.03.008--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Nitrogen balance negative13.13.01.010--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
Osteoporosis14.04.04.002; 15.02.03.002--
Pancreatitis07.18.01.001--
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
Paraesthesia17.02.06.005--
Paraparesis17.01.04.006--Not Available
Paraplegia17.01.04.007--Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.006--Not Available
Peptic ulcer07.04.07.001--Not Available
Personality change19.05.01.006; 17.02.05.019--
Petechiae24.07.06.004; 01.01.03.002; 23.06.01.003--Not Available
Pulmonary oedema02.05.02.003; 22.01.03.003--
Rash23.03.13.001--Not Available
Secondary adrenocortical insufficiency14.11.01.014; 05.01.02.003--Not Available
Seizure17.12.03.001--
Sensory disturbance17.02.07.006--Not Available
Skin atrophy23.01.05.001--
Skin hyperpigmentation23.05.01.003--
Skin hypopigmentation23.05.02.003--
Skin striae23.01.05.002--Not Available
Small intestinal perforation07.04.06.006--
Sodium retention14.05.04.003--Not Available
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