Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone sodium succinate
Drug ID BADD_D01091
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00978
MeSH ID D006854
PubChem ID 23694214
TTD Drug ID D0KR5B
NDC Product Code 55154-3942; 0009-0005; 0009-0016; 22552-0007; 64958-0020; 0009-0011; 0009-0825; 0009-0013
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C25H33NaO8
CAS Registry Number 125-04-2
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)COC(=O)CCC(=O)[O-])O)C)O.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T22658Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abscess sterile08.01.05.008--Not Available
Acne23.02.01.001--Not Available
Alkalosis hypokalaemic14.01.02.002--Not Available
Alopecia23.02.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arachnoiditis17.06.01.001; 12.02.04.002--
Arrhythmia02.03.02.001--Not Available
Blindness17.17.01.003; 06.02.02.001--Not Available
Bradycardia02.03.02.002--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Carbohydrate tolerance decreased13.02.02.003--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiomegaly02.04.02.001--Not Available
Cataract subcapsular06.06.01.002--Not Available
Circulatory collapse24.06.02.001--Not Available
Cushingoid14.11.01.006; 05.01.01.002; 24.08.02.004; 19.07.03.001--
Depression19.15.01.001--
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Dry skin23.03.03.001--
Ecchymosis01.01.03.001; 24.07.06.002; 23.06.01.001--Not Available
Erythema23.03.06.001--Not Available
Euphoric mood19.04.02.006--
Exophthalmos06.09.04.001; 05.02.02.002--Not Available
Fat embolism24.01.01.012; 12.01.08.003--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
The 1th Page    1 2 3 4    Next   Last    Total 4 Pages