Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone
Drug ID BADD_D01086
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00088
MeSH ID D006854
PubChem ID 5754
TTD Drug ID D0KR5B
NDC Product Code 73921-017; 68071-2233; 55910-225; 0168-0146; 64958-0036; 43136-203; 11673-842; 37946-7517; 0009-0012; 41167-0331; 76314-004; 45802-438; 38779-0009; 73921-015; 62011-0095; 73014-3050; 36800-981; 10631-407; 60722-1001; 41167-0108; 71863-109; 76420-028; 45802-937; 41167-0335; 0536-1277; 0113-0973; 41250-887; 62742-4077; 73408-633; 41167-0336; 68788-9922; 69473-017; 51326-108; 72189-276; 45334-327; 0009-5275; 68726-123; 47682-397; 68981-002; 41163-471; 11673-057; 69103-4506; 62559-431; 61269-343; 71516-001; 69729-103; 51672-2013; 68071-2546; 76420-161; 59088-268; 50382-024; 49035-732; 0009-0044; 21130-395; 63015-242; 41167-0339; 41520-201; 41167-0105; 51672-3004; 51672-3003; 62172-203; 59762-0073; 69842-809; 0395-8146; 68071-2261; 72789-227; 64958-0096; 42543-142; 41250-369; 72336-120; 45802-276; 62559-138; 55670-800; 67510-0065; 59779-878; 0096-0732; 63868-689; 0363-0670; 61010-4402; 68016-009; 24286-1560; 71216-3006; 65649-501; 70288-173; 73408-933; 49967-108; 60687-511; 82298-101; 41163-369; 70000-0543; 45865-630; 47682-398; 63629-2528; 62011-0096; 41167-0342; 11673-353; 42543-140; 41167-0039; 69396-069; 11673-399; 41415-047; 0472-0345; 50090-3434; 50090-0244; 36800-099; 24385-190; 0316-0186; 49035-707; 68062-9103; 50090-3115; 37946-7520; 37808-471; 0113-0541; 55910-646; 63629-8666; 68071-4878; 37946-6449; 53002-9660; 81238-4608; 11822-0680; 63941-312; 66267-969; 70518-3275; 68016-909; 69842-292; 0113-7006; 65649-401; 50090-3113; 69396-005; 72789-228; 63941-229; 67234-010; 69315-312; 55718-160; 69396-081; 59256-004; 41163-319; 68071-5205; 41415-048; 55621-001; 0574-0420; 50090-4094; 21130-278; 30142-369; 63629-2529; 21130-369; 53943-986; 55910-541; 53329-091; 69396-003; 37808-319; 0316-0128; 41167-0036; 63187-543; 63629-8335; 72789-229; 68788-9800; 69315-302; 45802-014; 50090-0350; 69729-269; 71863-111; 0316-0291; 43742-0563; 69396-028; 53145-430; 41520-319; 58624-0702; 68391-100; 68788-8078; 0472-0337; 43749-621; 62559-430; 37946-6503; 0363-1973; 79481-0319; 63187-575; 24385-274; 53943-269; 0009-0069; 64380-970; 0115-1696; 36800-051; 77052-010; 21130-993; 67510-0632; 57582-013; 76314-002; 67060-370; 72663-493; 11822-0499; 11822-0416; 68196-973; 0472-0339; 24385-021; 72288-369; 61919-364; 51927-0143; 41167-0035; 69842-345; 53002-8350; 50090-5856; 64958-0062; 79503-202; 63629-8667; 63629-8817; 0472-0343; 63187-504; 69396-096; 0168-0020; 71863-112; 63187-480; 71205-571; 58624-0703; 0179-8711; 76420-031; 65923-035; 42543-970; 68062-9108; 42543-141; 55315-181; 0316-0193; 71399-0120; 65923-393; 51822-021; 37946-7522; 11673-030; 72789-095; 68071-1581; 63629-1952; 41250-259; 59779-099; 53943-984; 51672-2063; 42213-370; 0168-0015; 63629-8668; 69396-017; 10356-120; 0573-0552; 41163-973; 53943-985; 0009-0031; 55621-018; 79481-8224; 66406-0050; 61010-5800; 51824-050; 50090-5470; 24385-276; 0904-7188; 0115-1700; 62135-020; 44577-623; 79572-018; 61269-345; 0363-0791; 71335-0812; 50090-2452; 63736-339; 50090-0527; 0404-0370; 51927-0144; 51927-0224; 43749-250; 37946-7518; 49348-441; 70000-0495; 79481-0471; 0316-0126; 69396-055; 59762-0074; 37808-973; 70934-350; 11822-2099; 73622-3050; 51672-2010; 76314-003; 71399-1246; 68016-063; 64025-0001; 36800-524; 43742-1275; 71399-0180; 79481-0973; 47682-933; 67091-419; 65923-925; 55700-321; 30142-541; 79903-091; 43749-620; 59762-0075; 69396-050; 0115-1697; 58624-0700; 30142-411; 71205-034; 36800-059; 55910-319
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C21H30O5
CAS Registry Number 50-23-7
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T226589169777; 12871375; 10348705; 9435641; 9631245; 12538206; 8902882; 15383152; 9717082
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Visual acuity reduced17.17.01.011; 06.02.03.0010.000224%
Vomiting07.01.07.0030.000894%
Weight decreased13.15.01.0050.000447%
Weight increased13.15.01.0060.000671%
White blood cell count increased13.01.06.0130.000224%Not Available
Multiple sclerosis relapse17.16.01.0030.000335%Not Available
Skin maceration23.03.03.016--Not Available
Hypoglycaemic seizure17.12.03.015; 14.06.03.002; 05.06.03.0020.000058%Not Available
Peripheral swelling08.01.03.053; 02.05.04.0150.000671%Not Available
Oesophagitis ulcerative07.04.05.003--Not Available
Lupus-like syndrome23.03.02.004; 15.06.02.004; 10.04.03.0030.000224%Not Available
Contusion23.03.11.002; 15.03.01.008; 12.01.06.001; 24.07.06.0010.000224%
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal stiffness15.03.01.0050.000224%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Growth retardation15.03.01.006--
Affect lability19.04.01.001--Not Available
Scleral thinning06.09.06.004--Not Available
Skin burning sensation17.02.06.009; 23.03.03.021--Not Available
Haemorrhage24.07.01.0020.000224%Not Available
Muscle mass15.05.03.018--Not Available
Cognitive disorder17.03.03.003; 19.21.02.001--
Application site folliculitis23.09.04.006; 12.07.01.044; 11.01.12.017; 08.02.01.044--Not Available
Connective tissue disorder15.06.01.006--Not Available
Embolism24.01.01.009--
Infarction24.04.02.0170.000058%Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Inflammation08.01.05.0070.000335%Not Available
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
The 9th Page    First    Pre   9 10    Next   Last    Total 10 Pages