Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone
Drug ID BADD_D01086
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00088
MeSH ID D006854
PubChem ID 5754
TTD Drug ID D0KR5B
NDC Product Code 73921-017; 68071-2233; 55910-225; 0168-0146; 64958-0036; 43136-203; 11673-842; 37946-7517; 0009-0012; 41167-0331; 76314-004; 45802-438; 38779-0009; 73921-015; 62011-0095; 73014-3050; 36800-981; 10631-407; 60722-1001; 41167-0108; 71863-109; 76420-028; 45802-937; 41167-0335; 0536-1277; 0113-0973; 41250-887; 62742-4077; 73408-633; 41167-0336; 68788-9922; 69473-017; 51326-108; 72189-276; 45334-327; 0009-5275; 68726-123; 47682-397; 68981-002; 41163-471; 11673-057; 69103-4506; 62559-431; 61269-343; 71516-001; 69729-103; 51672-2013; 68071-2546; 76420-161; 59088-268; 50382-024; 49035-732; 0009-0044; 21130-395; 63015-242; 41167-0339; 41520-201; 41167-0105; 51672-3004; 51672-3003; 62172-203; 59762-0073; 69842-809; 0395-8146; 68071-2261; 72789-227; 64958-0096; 42543-142; 41250-369; 72336-120; 45802-276; 62559-138; 55670-800; 67510-0065; 59779-878; 0096-0732; 63868-689; 0363-0670; 61010-4402; 68016-009; 24286-1560; 71216-3006; 65649-501; 70288-173; 73408-933; 49967-108; 60687-511; 82298-101; 41163-369; 70000-0543; 45865-630; 47682-398; 63629-2528; 62011-0096; 41167-0342; 11673-353; 42543-140; 41167-0039; 69396-069; 11673-399; 41415-047; 0472-0345; 50090-3434; 50090-0244; 36800-099; 24385-190; 0316-0186; 49035-707; 68062-9103; 50090-3115; 37946-7520; 37808-471; 0113-0541; 55910-646; 63629-8666; 68071-4878; 37946-6449; 53002-9660; 81238-4608; 11822-0680; 63941-312; 66267-969; 70518-3275; 68016-909; 69842-292; 0113-7006; 65649-401; 50090-3113; 69396-005; 72789-228; 63941-229; 67234-010; 69315-312; 55718-160; 69396-081; 59256-004; 41163-319; 68071-5205; 41415-048; 55621-001; 0574-0420; 50090-4094; 21130-278; 30142-369; 63629-2529; 21130-369; 53943-986; 55910-541; 53329-091; 69396-003; 37808-319; 0316-0128; 41167-0036; 63187-543; 63629-8335; 72789-229; 68788-9800; 69315-302; 45802-014; 50090-0350; 69729-269; 71863-111; 0316-0291; 43742-0563; 69396-028; 53145-430; 41520-319; 58624-0702; 68391-100; 68788-8078; 0472-0337; 43749-621; 62559-430; 37946-6503; 0363-1973; 79481-0319; 63187-575; 24385-274; 53943-269; 0009-0069; 64380-970; 0115-1696; 36800-051; 77052-010; 21130-993; 67510-0632; 57582-013; 76314-002; 67060-370; 72663-493; 11822-0499; 11822-0416; 68196-973; 0472-0339; 24385-021; 72288-369; 61919-364; 51927-0143; 41167-0035; 69842-345; 53002-8350; 50090-5856; 64958-0062; 79503-202; 63629-8667; 63629-8817; 0472-0343; 63187-504; 69396-096; 0168-0020; 71863-112; 63187-480; 71205-571; 58624-0703; 0179-8711; 76420-031; 65923-035; 42543-970; 68062-9108; 42543-141; 55315-181; 0316-0193; 71399-0120; 65923-393; 51822-021; 37946-7522; 11673-030; 72789-095; 68071-1581; 63629-1952; 41250-259; 59779-099; 53943-984; 51672-2063; 42213-370; 0168-0015; 63629-8668; 69396-017; 10356-120; 0573-0552; 41163-973; 53943-985; 0009-0031; 55621-018; 79481-8224; 66406-0050; 61010-5800; 51824-050; 50090-5470; 24385-276; 0904-7188; 0115-1700; 62135-020; 44577-623; 79572-018; 61269-345; 0363-0791; 71335-0812; 50090-2452; 63736-339; 50090-0527; 0404-0370; 51927-0144; 51927-0224; 43749-250; 37946-7518; 49348-441; 70000-0495; 79481-0471; 0316-0126; 69396-055; 59762-0074; 37808-973; 70934-350; 11822-2099; 73622-3050; 51672-2010; 76314-003; 71399-1246; 68016-063; 64025-0001; 36800-524; 43742-1275; 71399-0180; 79481-0973; 47682-933; 67091-419; 65923-925; 55700-321; 30142-541; 79903-091; 43749-620; 59762-0075; 69396-050; 0115-1697; 58624-0700; 30142-411; 71205-034; 36800-059; 55910-319
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C21H30O5
CAS Registry Number 50-23-7
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T226589169777; 12871375; 10348705; 9435641; 9631245; 12538206; 8902882; 15383152; 9717082
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin disorder23.03.03.0070.000224%Not Available
Skin exfoliation23.03.07.003--Not Available
Skin hyperpigmentation23.05.01.003--
Skin hypopigmentation23.05.02.003--
Skin infection23.09.04.002; 11.01.12.003--
Skin irritation23.03.04.009--Not Available
Skin striae23.01.05.002--Not Available
Somnolence19.02.05.003; 17.02.04.0060.000559%
Spinal compression fracture12.04.04.001; 15.08.05.004; 14.04.04.003--Not Available
Steroid withdrawal syndrome19.04.02.014; 08.06.02.013; 05.01.02.007--Not Available
Suicidal ideation19.12.01.0030.000224%
Swelling08.01.03.0150.000447%Not Available
Swelling face10.01.05.018; 23.04.01.0180.000224%Not Available
Syncope17.02.04.008; 02.01.02.008; 24.06.02.0120.000447%
Tachycardia02.03.02.007--Not Available
Telangiectasia24.03.03.003; 23.06.03.001--
Tendon rupture15.07.01.008; 12.01.07.0030.000224%Not Available
Thrombocytopenia01.08.01.0020.000224%Not Available
Thrombophlebitis24.01.02.001--Not Available
Tooth erosion07.09.05.002--Not Available
Tremor17.01.06.0020.000335%
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary tract infection20.08.02.001; 11.01.14.0040.000335%
Urticaria23.04.02.001; 10.01.06.0010.000335%
Uveitis10.02.01.023; 06.04.03.0030.000224%
Vaginal haemorrhage21.08.01.001; 24.07.03.0050.000447%
Vasculitis24.05.02.001; 10.02.02.006--
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
Vision blurred17.17.01.010; 06.02.06.0070.000224%
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