Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone
Drug ID BADD_D01086
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00088
MeSH ID D006854
PubChem ID 5754
TTD Drug ID D0KR5B
NDC Product Code 73921-017; 68071-2233; 55910-225; 0168-0146; 64958-0036; 43136-203; 11673-842; 37946-7517; 0009-0012; 41167-0331; 76314-004; 45802-438; 38779-0009; 73921-015; 62011-0095; 73014-3050; 36800-981; 10631-407; 60722-1001; 41167-0108; 71863-109; 76420-028; 45802-937; 41167-0335; 0536-1277; 0113-0973; 41250-887; 62742-4077; 73408-633; 41167-0336; 68788-9922; 69473-017; 51326-108; 72189-276; 45334-327; 0009-5275; 68726-123; 47682-397; 68981-002; 41163-471; 11673-057; 69103-4506; 62559-431; 61269-343; 71516-001; 69729-103; 51672-2013; 68071-2546; 76420-161; 59088-268; 50382-024; 49035-732; 0009-0044; 21130-395; 63015-242; 41167-0339; 41520-201; 41167-0105; 51672-3004; 51672-3003; 62172-203; 59762-0073; 69842-809; 0395-8146; 68071-2261; 72789-227; 64958-0096; 42543-142; 41250-369; 72336-120; 45802-276; 62559-138; 55670-800; 67510-0065; 59779-878; 0096-0732; 63868-689; 0363-0670; 61010-4402; 68016-009; 24286-1560; 71216-3006; 65649-501; 70288-173; 73408-933; 49967-108; 60687-511; 82298-101; 41163-369; 70000-0543; 45865-630; 47682-398; 63629-2528; 62011-0096; 41167-0342; 11673-353; 42543-140; 41167-0039; 69396-069; 11673-399; 41415-047; 0472-0345; 50090-3434; 50090-0244; 36800-099; 24385-190; 0316-0186; 49035-707; 68062-9103; 50090-3115; 37946-7520; 37808-471; 0113-0541; 55910-646; 63629-8666; 68071-4878; 37946-6449; 53002-9660; 81238-4608; 11822-0680; 63941-312; 66267-969; 70518-3275; 68016-909; 69842-292; 0113-7006; 65649-401; 50090-3113; 69396-005; 72789-228; 63941-229; 67234-010; 69315-312; 55718-160; 69396-081; 59256-004; 41163-319; 68071-5205; 41415-048; 55621-001; 0574-0420; 50090-4094; 21130-278; 30142-369; 63629-2529; 21130-369; 53943-986; 55910-541; 53329-091; 69396-003; 37808-319; 0316-0128; 41167-0036; 63187-543; 63629-8335; 72789-229; 68788-9800; 69315-302; 45802-014; 50090-0350; 69729-269; 71863-111; 0316-0291; 43742-0563; 69396-028; 53145-430; 41520-319; 58624-0702; 68391-100; 68788-8078; 0472-0337; 43749-621; 62559-430; 37946-6503; 0363-1973; 79481-0319; 63187-575; 24385-274; 53943-269; 0009-0069; 64380-970; 0115-1696; 36800-051; 77052-010; 21130-993; 67510-0632; 57582-013; 76314-002; 67060-370; 72663-493; 11822-0499; 11822-0416; 68196-973; 0472-0339; 24385-021; 72288-369; 61919-364; 51927-0143; 41167-0035; 69842-345; 53002-8350; 50090-5856; 64958-0062; 79503-202; 63629-8667; 63629-8817; 0472-0343; 63187-504; 69396-096; 0168-0020; 71863-112; 63187-480; 71205-571; 58624-0703; 0179-8711; 76420-031; 65923-035; 42543-970; 68062-9108; 42543-141; 55315-181; 0316-0193; 71399-0120; 65923-393; 51822-021; 37946-7522; 11673-030; 72789-095; 68071-1581; 63629-1952; 41250-259; 59779-099; 53943-984; 51672-2063; 42213-370; 0168-0015; 63629-8668; 69396-017; 10356-120; 0573-0552; 41163-973; 53943-985; 0009-0031; 55621-018; 79481-8224; 66406-0050; 61010-5800; 51824-050; 50090-5470; 24385-276; 0904-7188; 0115-1700; 62135-020; 44577-623; 79572-018; 61269-345; 0363-0791; 71335-0812; 50090-2452; 63736-339; 50090-0527; 0404-0370; 51927-0144; 51927-0224; 43749-250; 37946-7518; 49348-441; 70000-0495; 79481-0471; 0316-0126; 69396-055; 59762-0074; 37808-973; 70934-350; 11822-2099; 73622-3050; 51672-2010; 76314-003; 71399-1246; 68016-063; 64025-0001; 36800-524; 43742-1275; 71399-0180; 79481-0973; 47682-933; 67091-419; 65923-925; 55700-321; 30142-541; 79903-091; 43749-620; 59762-0075; 69396-050; 0115-1697; 58624-0700; 30142-411; 71205-034; 36800-059; 55910-319
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C21H30O5
CAS Registry Number 50-23-7
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T226589169777; 12871375; 10348705; 9435641; 9631245; 12538206; 8902882; 15383152; 9717082
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraparesis17.01.04.006--Not Available
Paraplegia17.01.04.007--Not Available
Peptic ulcer07.04.07.001--Not Available
Personality change17.02.05.019; 19.05.01.006--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.0020.000224%Not Available
Platelet count decreased13.01.04.0010.000559%
Pneumonia22.07.01.003; 11.01.09.0030.000783%Not Available
Prothrombin time prolonged13.01.02.0120.000224%Not Available
Prurigo23.03.04.017--Not Available
Pruritus23.03.12.0010.000447%
Psoriasis23.03.14.002; 10.02.01.0360.000447%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.000335%Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.0030.000783%
Rash23.03.13.0010.001118%Not Available
Rash maculo-papular23.03.13.004--
Rectal haemorrhage24.07.02.018; 07.12.03.0010.000224%
Renal failure20.01.03.0050.000117%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000224%
Rheumatoid arthritis15.01.03.001; 10.04.06.0010.000224%Not Available
Schizophrenia19.03.04.001--Not Available
Secondary adrenocortical insufficiency05.01.02.003; 14.11.01.014--Not Available
Seizure17.12.03.001--
Sensory disturbance17.02.07.0060.000224%Not Available
Sepsis11.01.11.0030.000058%
Shock24.06.02.002--Not Available
Sinusitis11.01.13.005; 22.07.03.0070.000335%
Skin atrophy23.01.05.001--
Skin depigmentation23.05.02.002--Not Available
Skin discolouration23.03.03.005--Not Available
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