Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Hydrocortisone
Drug ID BADD_D01086
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation.[L10529,L10532] Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions.[L10535] A hydrocortisone enema is indicated for ulcerative colitis,[L10538] a topical ointment with antibiotics is indicated for corticosteroid responsive dermatoses with infections,[L7772] and a topical cream with [acyclovir] is indicated to treat cold sores.[L7321] Oral granules of hydrocortisone are used as a replacement therapy for Adrenocortical Insufficiency (AI) in children under 17 years of age.[L16533]
Marketing Status approved; vet_approved
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00088
MeSH ID D006854
PubChem ID 5754
TTD Drug ID D0KR5B
NDC Product Code 76314-004; 38779-0009; 0904-7623; 51927-0143; 55718-159; 57582-013; 10356-120; 86014-200; 11673-057; 24286-1560; 30142-369; 0113-7006; 41167-0036; 41167-0331; 41167-0338; 41520-201; 0168-0146; 45334-327; 45802-276; 49035-973; 50090-5470; 51316-227; 51326-108; 51532-4608; 51672-2010; 51672-3004; 55910-646; 59088-209; 59256-004; 59779-878; 60687-582; 61010-5800; 63629-1952; 64980-301; 65923-035; 68062-9106; 68071-2818; 68788-8302; 0472-0321; 69842-155; 72189-276; 76348-585; 76348-804; 76420-028; 79481-0319; 37946-7520; 58624-0700; 11673-399; 11822-0471; 24385-276; 30142-541; 36800-524; 0115-1700; 41163-319; 41167-0342; 41167-0344; 42213-370; 43136-203; 43749-620; 45802-004; 49348-441; 50090-0350; 50090-5999; 50382-024; 51414-106; 55621-001; 55621-018; 55910-504; 62135-552; 63187-575; 63629-8667; 63736-339; 63868-689; 65923-393; 65923-925; 67234-010; 68016-099; 68016-102; 68071-1598; 69396-017; 70403-922; 71335-1989; 71399-0180; 72162-2018; 79481-0471; 79903-091; 0574-0420; 0904-7188; 49452-3580; 66406-0285; 68981-002; 11673-353; 21130-166; 24385-274; 0096-0732; 29784-142; 41163-471; 41163-973; 41167-0021; 41415-047; 0009-0044; 43136-103; 45802-014; 45802-937; 47682-397; 51822-021; 53002-9660; 53145-430; 53943-269; 53943-984; 58232-4010; 59088-268; 61269-345; 62135-551; 62172-203; 62282-504; 62559-138; 62559-430; 63187-543; 0363-1973; 63629-2529; 63629-8666; 63941-312; 65923-494; 67510-0065; 67510-0632; 68788-9922; 69315-312; 70518-3078; 70518-3275; 0573-0552; 71335-2044; 55301-201; 0316-0186; 0316-0193; 0316-0291; 59762-0073; 59762-0075; 61010-4402; 63629-2527; 63824-851; 63941-229; 0394-0859; 68071-2897; 68726-123; 68726-504; 69396-050; 69396-118; 69473-017; 69842-192; 70288-714; 71205-034; 72189-209; 76314-003; 79903-092; 55718-160; 58624-0703; 81918-001; 11673-398; 11822-2099; 36800-939; 0115-1696; 41167-0033; 41167-0039; 41167-0105; 41167-0108; 41167-0330; 41167-0336; 41250-887; 44911-0275; 45865-630; 0178-0455; 49035-732; 50268-407; 51414-107; 51824-050; 53002-8350; 53002-9662; 53329-091; 61269-343; 62011-0095; 62011-0096; 62135-020; 0363-0670; 63015-242; 63187-567; 64380-970; 65649-501; 68062-2264; 68071-2233; 68071-2261; 68391-100; 69396-028; 69396-055; 69842-292; 70000-0495; 71516-342; 72789-228; 37946-7518; 30142-411; 0113-1369; 36800-471; 36800-981; 41167-0032; 41167-0035; 41520-319; 42543-971; 42543-972; 0168-0015; 0168-0080; 43742-1275; 43749-250; 47682-211; 51672-2013; 53943-985; 55700-321; 55910-541; 59651-415; 59762-0074; 61269-339; 63187-504; 63868-955; 68016-063; 68071-5205; 68788-8455; 69396-005; 69968-0511; 76314-002; 79481-0973; 79503-202; 0924-5633; 60722-1001; 21130-395; 24385-021; 0113-0471; 0113-0541; 0113-0973; 0115-1697; 37808-973; 41167-0335; 41250-369; 0168-0020; 44577-623; 50090-0527; 55315-182; 59779-729; 62135-186; 62742-4077; 63187-480; 63629-8668; 63629-9057; 63736-029; 64380-971; 65649-401; 67091-419; 68016-909; 68062-9103; 68788-8078; 0472-0337; 69103-4506; 69396-081; 69729-269; 71101-800; 71399-0120; 73408-933; 73408-981; 76420-110; 0009-0069; 22552-0037; 37946-6503; 51927-0144; 10107-429; 59929-107; 64025-0001; 64958-0008; 64958-0096; 66406-0050; 71216-3006; 82298-101; 11527-052; 11673-202; 11673-842; 24385-190; 30142-973; 36800-018; 36800-059; 37808-319; 37808-471; 41167-0028; 41520-033; 42543-970; 47682-398; 49035-707; 49967-108; 51316-230; 51672-3003; 52410-3050; 55315-181; 0316-0128; 62559-431
UNII WI4X0X7BPJ
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C21H30O5
CAS Registry Number 50-23-7
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Viral infection11.05.04.001--Not Available
Vision blurred17.17.01.010; 06.02.06.0070.000092%
Visual acuity reduced06.02.10.012; 17.17.01.0110.000046%
Visual impairment06.02.10.0130.000046%Not Available
Vomiting07.01.07.0030.000489%
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Wheezing22.03.01.0090.000161%
Multiple sclerosis relapse17.16.01.0030.000069%Not Available
Skin maceration23.03.03.016--Not Available
Poor venous access24.03.02.0170.000046%Not Available
Hypoglycaemic seizure17.12.03.015; 14.06.03.002; 05.06.03.0020.000046%Not Available
Peripheral swelling08.01.03.053; 02.05.04.0150.000217%Not Available
Weight fluctuation14.03.02.002--Not Available
Oesophagitis ulcerative07.04.05.003--Not Available
General physical health deterioration08.01.03.018--Not Available
Balance disorder08.01.03.081; 17.02.02.007--Not Available
Lupus-like syndrome23.03.02.004; 15.06.02.004; 10.04.03.0030.000046%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Acute coronary syndrome02.02.02.015; 24.04.04.011--Not Available
Eye pruritus06.04.05.006--Not Available
Ocular discomfort06.08.03.008--Not Available
Periventricular leukomalacia18.04.07.003; 17.13.02.0050.000046%Not Available
Musculoskeletal stiffness15.03.05.0270.000046%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Injection site swelling08.02.03.017; 12.07.03.0180.000180%Not Available
Type IV hypersensitivity reaction10.01.03.022--Not Available
Growth retardation05.03.02.007; 15.03.05.016; 14.03.02.031--
Affect lability19.04.01.001--Not Available
Scleral thinning06.09.06.004--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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