Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocortisone
Drug ID BADD_D01086
Description Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.[A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also used to treat endocrine (hormonal) disorders (adrenal insufficiency, Addisons disease). It is also used to treat many immune and allergic disorders, such as arthritis, lupus, severe psoriasis, severe asthma, ulcerative colitis, and Crohn's disease.
Marketing Status Prescription; Discontinued
ATC Code A01AC03; A07EA02; C05AA01; D07AA02; D07XA01; H02AB09; S01BA02; S01CB03; S02BA01
DrugBank ID DB00741
KEGG ID D00088
MeSH ID D006854
PubChem ID 5754
TTD Drug ID D0KR5B
NDC Product Code 73921-017; 68071-2233; 55910-225; 0168-0146; 64958-0036; 43136-203; 11673-842; 37946-7517; 0009-0012; 41167-0331; 76314-004; 45802-438; 38779-0009; 73921-015; 62011-0095; 73014-3050; 36800-981; 10631-407; 60722-1001; 41167-0108; 71863-109; 76420-028; 45802-937; 41167-0335; 0536-1277; 0113-0973; 41250-887; 62742-4077; 73408-633; 41167-0336; 68788-9922; 69473-017; 51326-108; 72189-276; 45334-327; 0009-5275; 68726-123; 47682-397; 68981-002; 41163-471; 11673-057; 69103-4506; 62559-431; 61269-343; 71516-001; 69729-103; 51672-2013; 68071-2546; 76420-161; 59088-268; 50382-024; 49035-732; 0009-0044; 21130-395; 63015-242; 41167-0339; 41520-201; 41167-0105; 51672-3004; 51672-3003; 62172-203; 59762-0073; 69842-809; 0395-8146; 68071-2261; 72789-227; 64958-0096; 42543-142; 41250-369; 72336-120; 45802-276; 62559-138; 55670-800; 67510-0065; 59779-878; 0096-0732; 63868-689; 0363-0670; 61010-4402; 68016-009; 24286-1560; 71216-3006; 65649-501; 70288-173; 73408-933; 49967-108; 60687-511; 82298-101; 41163-369; 70000-0543; 45865-630; 47682-398; 63629-2528; 62011-0096; 41167-0342; 11673-353; 42543-140; 41167-0039; 69396-069; 11673-399; 41415-047; 0472-0345; 50090-3434; 50090-0244; 36800-099; 24385-190; 0316-0186; 49035-707; 68062-9103; 50090-3115; 37946-7520; 37808-471; 0113-0541; 55910-646; 63629-8666; 68071-4878; 37946-6449; 53002-9660; 81238-4608; 11822-0680; 63941-312; 66267-969; 70518-3275; 68016-909; 69842-292; 0113-7006; 65649-401; 50090-3113; 69396-005; 72789-228; 63941-229; 67234-010; 69315-312; 55718-160; 69396-081; 59256-004; 41163-319; 68071-5205; 41415-048; 55621-001; 0574-0420; 50090-4094; 21130-278; 30142-369; 63629-2529; 21130-369; 53943-986; 55910-541; 53329-091; 69396-003; 37808-319; 0316-0128; 41167-0036; 63187-543; 63629-8335; 72789-229; 68788-9800; 69315-302; 45802-014; 50090-0350; 69729-269; 71863-111; 0316-0291; 43742-0563; 69396-028; 53145-430; 41520-319; 58624-0702; 68391-100; 68788-8078; 0472-0337; 43749-621; 62559-430; 37946-6503; 0363-1973; 79481-0319; 63187-575; 24385-274; 53943-269; 0009-0069; 64380-970; 0115-1696; 36800-051; 77052-010; 21130-993; 67510-0632; 57582-013; 76314-002; 67060-370; 72663-493; 11822-0499; 11822-0416; 68196-973; 0472-0339; 24385-021; 72288-369; 61919-364; 51927-0143; 41167-0035; 69842-345; 53002-8350; 50090-5856; 64958-0062; 79503-202; 63629-8667; 63629-8817; 0472-0343; 63187-504; 69396-096; 0168-0020; 71863-112; 63187-480; 71205-571; 58624-0703; 0179-8711; 76420-031; 65923-035; 42543-970; 68062-9108; 42543-141; 55315-181; 0316-0193; 71399-0120; 65923-393; 51822-021; 37946-7522; 11673-030; 72789-095; 68071-1581; 63629-1952; 41250-259; 59779-099; 53943-984; 51672-2063; 42213-370; 0168-0015; 63629-8668; 69396-017; 10356-120; 0573-0552; 41163-973; 53943-985; 0009-0031; 55621-018; 79481-8224; 66406-0050; 61010-5800; 51824-050; 50090-5470; 24385-276; 0904-7188; 0115-1700; 62135-020; 44577-623; 79572-018; 61269-345; 0363-0791; 71335-0812; 50090-2452; 63736-339; 50090-0527; 0404-0370; 51927-0144; 51927-0224; 43749-250; 37946-7518; 49348-441; 70000-0495; 79481-0471; 0316-0126; 69396-055; 59762-0074; 37808-973; 70934-350; 11822-2099; 73622-3050; 51672-2010; 76314-003; 71399-1246; 68016-063; 64025-0001; 36800-524; 43742-1275; 71399-0180; 79481-0973; 47682-933; 67091-419; 65923-925; 55700-321; 30142-541; 79903-091; 43749-620; 59762-0075; 69396-050; 0115-1697; 58624-0700; 30142-411; 71205-034; 36800-059; 55910-319
Synonyms Hydrocortisone | Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- | Cortisol | Cortef | Hydrocortisone, (11 alpha)-Isomer | Epicortisol | 11-Epicortisol | 11 Epicortisol | Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer | Cortifair | Cortril
Chemical Information
Molecular Formula C21H30O5
CAS Registry Number 50-23-7
SMILES CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
InflammationInterleukin-8P10145T226589169777; 12871375; 10348705; 9435641; 9631245; 12538206; 8902882; 15383152; 9717082
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.0020.000447%
Abdominal pain upper07.01.05.0030.000335%
Abscess11.01.08.001--Not Available
Acne23.02.01.0010.000335%Not Available
Acne infantile23.02.01.006--Not Available
Adrenocortical insufficiency acute05.01.02.005; 14.11.01.0200.000224%Not Available
Agitation19.06.02.001; 17.02.05.0120.000224%
Alanine aminotransferase increased13.03.01.003--
Alkalosis hypokalaemic14.01.02.002--Not Available
Alopecia23.02.02.0010.000559%
Amenorrhoea21.01.02.001; 05.05.01.002--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000224%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.0020.000559%
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Application site pain12.07.01.004; 08.02.01.004--Not Available
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Arachnoiditis17.06.01.001; 12.02.04.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.0010.000894%
Arthropathy15.01.01.0030.000224%Not Available
Asthenia08.01.01.0010.000559%Not Available
Asthma22.03.01.002; 10.01.03.0100.000224%Not Available
Atrophy08.03.04.001--Not Available
Back pain15.03.04.0050.000783%
Benign intracranial hypertension17.07.02.001--Not Available
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