Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocodone
Drug ID BADD_D01084
Description Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025]
Indications and Usage For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.
Marketing Status Discontinued; Prescription
ATC Code R05DA03
DrugBank ID DB00956
KEGG ID D08045
MeSH ID D006853
PubChem ID 5284569
TTD Drug ID D0X5KF
NDC Product Code 81842-617
Synonyms Hydrocodone | Hydrocodon | Dihydrocodeinone | Dicodid | Robidone | Hydrocodone Bitartrate | Hydrocodone Tartrate (1:1), Hydrate (2:5) | Hydrocodeinonebitartrate | Hydrocon | Codinovo | Hycodan | Hycon
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 125-29-1
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pain in extremity15.03.04.0100.000291%
Palpitations02.01.02.0030.000436%
Paraesthesia17.02.06.005--
Pruritus23.03.12.0010.000727%
Rash23.03.13.0010.000581%Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Rhinorrhoea22.02.05.0100.000291%
Seizure17.12.03.001--
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Thrombocytopenia01.08.01.002--Not Available
Tremor17.01.06.0020.000581%
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urinary retention20.02.02.011--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.0010.000291%
Vision blurred17.17.01.010; 06.02.06.0070.000291%
Vomiting07.01.07.0030.001308%
Weight decreased13.15.01.0050.000436%
Withdrawal syndrome19.07.02.005; 08.06.02.012--Not Available
Hypoacusis04.02.01.006--
Muscle strain15.05.07.002; 12.01.07.004--Not Available
Contusion24.07.06.001; 23.03.11.002; 15.03.01.008; 12.01.06.0010.000436%
Ureteral spasm20.06.01.002--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 08.01.03.027; 21.02.02.001--
Joint injury12.04.03.005--Not Available
Connective tissue disorder15.06.01.006--Not Available
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