Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrocodone
Drug ID BADD_D01084
Description Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025]
Indications and Usage For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.
Marketing Status Discontinued; Prescription
ATC Code R05DA03
DrugBank ID DB00956
KEGG ID D08045
MeSH ID D006853
PubChem ID 5284569
TTD Drug ID D0X5KF
NDC Product Code 81842-617
Synonyms Hydrocodone | Hydrocodon | Dihydrocodeinone | Dicodid | Robidone | Hydrocodone Bitartrate | Hydrocodone Tartrate (1:1), Hydrate (2:5) | Hydrocodeinonebitartrate | Hydrocon | Codinovo | Hycodan | Hycon
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 125-29-1
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.000436%Not Available
Abdominal distension07.01.04.0010.000436%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.000727%
Agitation19.06.02.001; 17.02.05.0120.000291%
Agranulocytosis01.02.03.001--Not Available
Anxiety19.06.02.0020.000291%
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000114%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.000076%Not Available
Constipation07.02.02.001--
Cough22.02.03.001--
Deafness04.02.01.001--Not Available
Dehydration14.05.05.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.000872%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.000872%
Drug abuse19.07.02.0100.000114%Not Available
Drug hypersensitivity10.01.01.0010.000436%Not Available
Drug interaction08.06.03.001--Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.000727%Not Available
Dry mouth07.06.01.002--
Dysphagia07.01.06.0030.000291%
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.0020.000436%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.000872%Not Available
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