| Drug Name |
Hyaluronidase (human recombinant) |
| Drug ID |
BADD_D01079 |
| Description |
A purified preparation of the enzyme recombinant human hyaluronidase. Hyaluronidase (human recombinant) (INN Vorhyaluronidase alfa) is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase (PH20).[A4033] Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.[L13338] The action of hyaluronidase was first described in 1936, and named in 1939.[A199026] Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue.[A199026] Hyaluronidase has been used in surgical settings for at least the past 60 years to improve the diffusion of local anesthetics.[A199047]
Hyaluronidase was first used in prescription products in the United States on 5 May 2004.[L13338] |
| Indications and Usage |
Indicated as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
B06AA03 |
| DrugBank ID |
DB06205
|
| KEGG ID |
D04456
|
| MeSH ID |
D006821
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
18657-117; 50090-4534 |
| Synonyms |
Hyaluronoglucosaminidase | Hyaluronidase | Hyaglosidase | Hyaluronate Hydrolase | Hydrolase, Hyaluronate | Duran-Reynals Permeability Factor | Duran Reynals Permeability Factor | Factor, Duran-Reynals Permeability | Permeability Factor, Duran-Reynals | GL Enzyme | Wydase |
