Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Guanethidine monosulfate
Drug ID BADD_D01045
Description An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem]
Indications and Usage For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
Marketing Status Discontinued
ATC Code C02CC02; S01EX01
DrugBank ID DB01170
KEGG ID D04382
MeSH ID D006145
PubChem ID 56927696
TTD Drug ID D0N3PE
NDC Product Code Not Available
Synonyms Guanethidine | Oktadin | ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine | Octadine | Guanethidine Sulfate | Sulfate, Guanethidine | Guanethidine Sulfate (2:1) | Guanethidine Sulfate (1:2) | Ismelin | Isobarin | Guanethidine Monosulfate | Monosulfate, Guanethidine | Guanethidine Sulfate (1:1) | Guanethidine Sulfate (2:1), 14C-Labeled
Chemical Information
Molecular Formula C10H24N4O4S
CAS Registry Number 60-02-6
SMILES [H+].[H+].C1CCCN(CCC1)CCN=C(N)N.[O-]S(=O)(=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Blood urea increased13.13.01.006--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Ejaculation delayed21.03.01.001--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Fatigue08.01.01.002--
Frequent bowel movements07.02.04.002--Not Available
Leukopenia01.02.02.001--Not Available
Myalgia15.05.02.001--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Nocturia20.02.03.001--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Priapism21.03.01.005--Not Available
Salivary gland pain07.06.02.002--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Thrombocytopenia01.08.01.002--Not Available
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