Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Goserelin
Drug ID BADD_D01038
Description Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
Indications and Usage Goserelin is indicated for: - Use in combination with flutamide for the management of locally confined carcinoma of the prostate - Palliative treatment of advanced carcinoma of the prostate - The management of endometriosis - Use as an endometrial-thinning agent prior to endometrial ablation for dysfunctional uterine bleeding - Use in the palliative treatment of advanced breast cancer in pre- and perimenopausal women
Marketing Status approved
ATC Code L02AE03
DrugBank ID DB00014
KEGG ID D04405
MeSH ID D017273
PubChem ID 5311128
TTD Drug ID D00BCG
NDC Product Code 55463-0005; 70720-951; 70720-950
UNII 0F65R8P09N
Synonyms Goserelin | ICI-118630 | ICI 118630 | ICI118630 | Zoladex | Goserelin Acetate | Acetate, Goserelin
Chemical Information
Molecular Formula C59H84N18O14
CAS Registry Number 65807-02-5
SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C( CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C 6CCC(=O)N6
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Breast cancer female21.05.01.011; 16.10.01.0040.000334%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.000667%
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000334%Not Available
Vasodilation procedure25.03.01.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.007741%
Prostate cancer21.04.02.002; 16.25.01.0010.000501%Not Available
Abdominal hernia07.16.06.0050.000334%Not Available
Breast cancer male21.05.01.008; 16.10.01.0020.000334%Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.11.01.0030.001001%Not Available
Infarction24.04.02.017--Not Available
Limb discomfort15.03.04.0140.000334%Not Available
Intra-abdominal haemorrhage12.01.17.011; 24.07.02.035; 07.12.02.0080.000734%
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.0010.000334%
Ill-defined disorder08.01.03.049--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Pituitary tumour benign16.37.02.001; 05.03.05.0030.000501%Not Available
Adverse drug reaction08.06.01.009--Not Available
Disease progression08.01.03.0380.001168%
Psychotic disorder19.03.01.0020.000334%
Hyperlipidaemia14.08.03.001--
Metastasis16.22.01.0010.000334%Not Available
Renal impairment20.01.03.010--Not Available
Cystitis noninfective20.03.02.001--
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.003837%
The 11th Page    First    Pre   11 12    Next   Last    Total 12 Pages