Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Goserelin
Drug ID BADD_D01038
Description Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
Indications and Usage Used to treat hormone-sensitive cancers of the breast (in pre- and peri- menopausal women) and prostate, and some benign gynaecological disorders (endometriosis, uterine fibroids and endometrial thinning). In addition, goserelin is used in assisted reproduction and in the treatment of precocious puberty.
Marketing Status Prescription
ATC Code L02AE03
DrugBank ID DB00014
KEGG ID D04405
MeSH ID D017273
PubChem ID 5311128
TTD Drug ID D00BCG
NDC Product Code 70720-951; 55463-0005; 70720-950
Synonyms Goserelin | ICI-118630 | ICI 118630 | ICI118630 | Zoladex | Goserelin Acetate | Acetate, Goserelin
Chemical Information
Molecular Formula C59H84N18O14
CAS Registry Number 65807-02-5
SMILES CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C( CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C 6CCC(=O)N6
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Affect lability19.04.01.001--Not Available
Bone cancer metastatic16.29.02.001; 15.09.03.004--Not Available
Haemorrhage24.07.01.0020.002206%Not Available
Intra-abdominal haematoma24.07.02.034; 07.12.02.0050.002206%Not Available
Muscle mass15.05.03.018--Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.001471%
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.000384%Not Available
Vasodilation procedure25.03.01.001--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Angiopathy24.03.02.007--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.019858%
Prostate cancer21.04.02.002; 16.25.01.0010.000576%Not Available
Breast disorder21.05.04.0040.001471%Not Available
Cardiac disorder02.01.01.0030.000959%Not Available
Hormone level abnormal13.10.10.0010.001471%Not Available
Infarction24.04.02.017--Not Available
Intra-abdominal haemorrhage24.07.02.035; 07.12.02.0080.001471%
Malnutrition14.03.02.004--Not Available
Mental disorder19.07.01.002--Not Available
Neoplasm progression16.16.02.0050.000384%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.0010.001471%
Ill-defined disorder08.01.03.049--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Pituitary tumour benign05.03.05.003; 16.37.02.0010.002206%Not Available
Disease progression08.01.03.0380.000959%
Psychotic disorder19.03.01.0020.001471%
Hyperlipidaemia14.08.03.001--
Metastasis16.22.01.0010.000384%Not Available
Renal impairment20.01.03.010--Not Available
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