Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gatifloxacin
Drug ID BADD_D01006
Description Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan.
Indications and Usage For the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes
Marketing Status Prescription; Discontinued
ATC Code J01MA16; S01AE06
DrugBank ID DB01044
KEGG ID D00589
MeSH ID D000077734
PubChem ID 5379
TTD Drug ID D03CQE
NDC Product Code 13668-526; 60758-615; 61314-672; 53476-1155; 68180-435; 0023-3615; 50383-189
Synonyms Gatifloxacin | 1-cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | Gatifloxacine | Tequin | AM 1155 | AM-1155 | CG 5501 | BMS-206584 | BMS 206584 | BMS206584 | Zymar
Chemical Information
Molecular Formula C19H22FN3O4
CAS Registry Number 112811-59-3
SMILES CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Parosmia22.04.03.007; 17.04.04.002--Not Available
Pharyngitis07.05.07.004; 22.07.03.004; 11.01.13.003--
Photophobia17.17.02.006; 06.01.01.004--
Photosensitivity reaction23.03.09.003--
Pruritus23.03.12.001--
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Punctate keratitis06.04.02.003--Not Available
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rash pustular23.03.10.003; 11.01.12.002--
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rhinorrhoea22.02.05.010--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sneezing22.02.05.011--
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome12.03.01.014; 11.07.01.005; 10.01.03.020; 23.03.01.007--
Stomatitis07.05.06.005--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tendon rupture15.07.01.008; 12.01.07.003--Not Available
Tension19.06.02.005--Not Available
Thinking abnormal17.02.05.023; 19.10.03.001--Not Available
Thirst14.03.02.007; 08.01.09.021--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tongue disorder07.14.01.002--Not Available
Tongue oedema07.14.02.007; 23.04.01.009; 10.01.05.008--Not Available
Torsade de pointes02.03.04.005--Not Available
Tremor17.01.06.002--
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