Pharmaceutical Information |
Drug Name |
Galsulfase |
Drug ID |
BADD_D01001 |
Description |
Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family. |
Indications and Usage |
For the treatment of adults and children with Mucopolysaccharidosis VI. |
Marketing Status |
Prescription |
ATC Code |
A16AB08 |
DrugBank ID |
DB01279
|
KEGG ID |
D06565
|
MeSH ID |
C508864
|
PubChem ID |
Not Available
|
TTD Drug ID |
D05UHF
|
NDC Product Code |
68135-020 |
Synonyms |
galsulfase | Naglazyme |
|
Chemical Information |
Molecular Formula |
Not Available |
CAS Registry Number |
552858-79-4 |
SMILES |
Not Available |
Chemical Structure |
|
|
ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
|
ADRs Induced by Drug |
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