Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadobenate dimeglumine
Drug ID BADD_D00983
Description Gadobenic acid (in the form of gadobenate dimeglumine) is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and transient binding capacity to serum proteins. This binding leads to an increased relaxivity of gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other agents.
Indications and Usage Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
Marketing Status Prescription
ATC Code V08CA08
DrugBank ID DB00743
KEGG ID D04283
MeSH ID C064572
PubChem ID 105125
TTD Drug ID D01OIL
NDC Product Code 0270-5264; 57876-333; 0270-5164
Synonyms gadobenic acid | 3,6,9-triaza-12-oxa-3,6,9-tricarboxymethylene-10-carboxy-13-phenyltridecanoic acid, gadolinium | Gd-BOPTA | gadobenic acid, dimeglumine salt | gadobenate dimeglumine | gadolinium-BOPTA-Dimeg | MultiHance | Gd(BOPTA)2 | B 19036 | B-19036 | gadolinium-benzyloxypropionyl tetraacetate
Chemical Information
Molecular Formula C22H31N3O11
CAS Registry Number 113786-33-7
SMILES C1=CC=C(C=C1)COCC(C(=O)O)N(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tongue oedema23.04.01.009; 10.01.05.008; 07.14.02.007--Not Available
Tonsillitis11.01.13.006; 22.07.03.008--Not Available
Torsade de pointes02.03.04.005--Not Available
Transferrin13.11.01.046--Not Available
Tremor17.01.06.002--
Urethral disorder20.07.01.002--Not Available
Urinary incontinence20.02.02.010; 17.05.01.008--
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urine abnormality20.02.01.013--Not Available
Urticaria23.04.02.001; 10.01.06.001--
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Visual acuity reduced17.17.01.011; 06.02.03.001--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Wheezing22.03.01.009--
White blood cell count decreased13.01.06.012--
White blood cell count increased13.01.06.013--Not Available
Hypoacusis04.02.01.006--
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.006--
Vascular graft occlusion24.04.02.019; 12.02.01.016--Not Available
Contusion24.07.06.001; 15.03.01.008; 23.03.11.002; 12.01.06.001--
Deep vein thrombosis24.01.02.003--Not Available
Respiratory tract congestion22.02.07.003--Not Available
Lymphatic disorder01.09.01.003--Not Available
Thoracic operation25.13.05.001--Not Available
Protein urine present13.13.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Injection site swelling12.07.03.018; 08.02.03.017--Not Available
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