ADReCS

Pharmaceutical Information

Drug Name	Furosemide
Drug ID	BADD_D00979
Description	Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.[L7958] Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.[L7961] It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.[A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.[L7958]
Indications and Usage	Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.[L7958] Oral furosemide is indicated alone for the management of mild to moderate hypertension or severe hypertension in combination with other antihypertensive medications.[L9659] Intravenous furosemide is indicated as adjunctive therapy in acute pulmonary edema when a rapid onset of diuresis is desired.[L7958]
Marketing Status	approved; vet_approved
ATC Code	C03CA01
DrugBank ID	DB00695
KEGG ID	D00331
MeSH ID	D005665
PubChem ID	3440
TTD Drug ID	D0PQ3G
NDC Product Code	72603-474; 51552-0940; 51927-0077; 53002-4300; 55150-323; 61919-442; 63323-280; 63629-1120; 0378-0208; 0404-9864; 68083-432; 68083-433; 68083-434; 0409-6102; 70121-1076; 70860-302; 70934-737; 71335-0384; 71872-7236; 0615-8369; 0904-7177; 36000-063; 43063-849; 51655-310; 55154-9582; 66432-549; 67296-1469; 68071-1708; 68071-1809; 68071-4445; 69315-118; 70756-619; 72789-032; 63415-0025; 43063-806; 43353-747; 43547-402; 51079-073; 51662-1572; 60760-708; 63187-097; 63187-437; 63187-739; 69844-051; 70518-0050; 70518-0251; 70756-620; 70934-111; 0054-4297; 0054-4301; 0054-8297; 71872-7295; 60760-707; 63187-517; 63629-1216; 0378-0232; 64980-564; 67296-1547; 68071-3461; 68788-7354; 69315-116; 0054-3294; 71335-0842; 71335-1632; 0054-8299; 71610-636; 71872-7277; 72789-033; 72789-157; 42291-468; 42708-174; 43353-018; 43353-341; 43547-401; 50090-2560; 51407-113; 51407-114; 51662-1336; 52584-284; 63629-1119; 63629-1217; 64980-562; 0404-9863; 68094-756; 68094-867; 69315-117; 69844-052; 70121-1163; 70529-550; 71335-0397; 71872-7278; 49452-3222; 57451-0007; 36000-283; 43353-069; 50090-5429; 51655-481; 51662-1226; 51662-1574; 58118-0143; 60760-858; 70121-1164; 70518-0809; 70518-2766; 70529-061; 0054-3298; 72789-030; 48087-0053; 51927-1784; 71052-238; 30698-060; 30698-067; 36000-282; 60760-217; 61919-255; 63629-1215; 0378-0216; 64679-759; 68071-2313; 68071-3273; 70518-0836; 70529-062; 70529-549; 0054-8301; 71610-096; 71610-635; 0615-8370; 72603-251; 83284-002; 16729-500; 25021-311; 36000-284; 43547-403; 50090-5702; 50090-6219; 50090-6221; 51662-1227; 63187-506; 68071-4022; 71610-049; 17337-0087; 72166-003; 16729-502; 23155-473; 42708-123; 43063-702; 50090-3313; 50090-3338; 51079-072; 51079-527; 51407-115; 52584-283; 55150-322; 55150-324; 55154-2365; 63187-790; 63629-1214; 66432-550; 68071-3459; 68788-6784; 70518-3757; 70756-618; 0054-4299; 71288-203; 71335-0601; 71610-634; 71872-7127; 72572-190; 0904-7178; 57451-0006; 66326-401; 70193-0002; 42291-469; 53808-1109; 55154-4452; 55154-9581; 55700-452; 61919-242; 64980-563; 0404-9862; 0409-1639; 68788-6948; 68788-7265; 69844-053; 70518-3061; 71335-0852; 71610-284; 71872-7059; 0615-8368; 72603-133; 81565-201; 48087-0054; 51927-0078; 82348-105; 16729-501; 17224-178; 30698-066; 36000-064; 36000-065; 42291-470; 43063-716; 50090-3339; 51662-1575; 55154-2364; 55700-461
UNII	7LXU5N7ZO5
Synonyms	Furosemide \| Frusemide \| Fursemide \| Frusemid \| Fusid \| Lasix \| Furosemide Monohydrochloride \| Errolon \| Furanthril \| Furantral \| Furosemide Monosodium Salt

Chemical Information

Molecular Formula	C12H11ClN2O5S
CAS Registry Number	54-31-9
SMILES	C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Respiratory symptom	22.12.02.013	0.000014%		Not Available
Sinus node dysfunction	02.03.03.017	0.000014%
Multiple organ dysfunction syndrome	08.01.03.057	0.000153%
Adenocarcinoma gastric	16.13.03.002; 07.21.02.002	0.000014%		Not Available
Cardiac failure chronic	02.05.01.009	0.000035%		Not Available
Cerebellar haemorrhage	24.07.04.023; 17.08.01.046	0.000014%		Not Available
Concomitant disease aggravated	08.01.03.063	0.000042%		Not Available
Confabulation	19.10.03.009	0.000035%		Not Available
Cyanosis central	02.11.04.005; 22.02.02.012	0.000014%		Not Available
Dermatitis exfoliative generalised	23.03.07.002; 10.01.01.029	0.000021%		Not Available
Hyperaldosteronism	14.05.04.006; 05.01.01.006; 24.08.04.005	0.000021%		Not Available
Hyponatraemic syndrome	14.05.04.009	0.000090%		Not Available
Metastases to pleura	22.05.04.002; 16.22.02.022	0.000014%		Not Available
Renal atrophy	20.01.06.001	0.000028%		Not Available
Thyrotoxic periodic paralysis	14.11.01.045; 05.02.02.005; 17.01.04.021	0.000014%		Not Available
Vitamin B1 deficiency	14.12.02.012	0.000111%		Not Available
Wernicke's encephalopathy	17.13.01.013; 14.12.02.013	0.000028%		Not Available
Shoshin beriberi	14.12.02.010; 02.05.03.006	0.000028%		Not Available
Silent myocardial infarction	24.04.04.025; 02.02.02.022	0.000014%		Not Available
Intracranial hypotension	12.01.10.008; 17.02.05.036	0.000028%		Not Available
Small intestinal haemorrhage	24.07.02.019; 07.12.03.002	0.000014%
Lymphangiosis carcinomatosa	24.09.02.007; 16.22.02.009; 01.09.01.027	0.000014%		Not Available
Non-alcoholic steatohepatitis	14.08.04.024; 09.01.07.035	0.000014%		Not Available
Gastrointestinal tract mucosal pigmentation	07.11.03.009	0.000042%		Not Available
Cell death	14.11.02.005; 08.03.03.003	0.000014%		Not Available
Nephrogenic anaemia	20.01.01.007; 01.03.04.001	0.000014%		Not Available
Parakeratosis	23.03.03.067	0.000014%		Not Available
Sopor	19.02.04.002; 17.02.04.021	0.000153%		Not Available
Acquired macroglossia	07.14.01.009	0.000035%		Not Available
Renal cyst haemorrhage	16.27.01.005; 24.07.07.003; 20.01.04.017	0.000014%		Not Available

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