Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fosaprepitant dimeglumine
Drug ID BADD_D00963
Description Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Indications and Usage For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
Marketing Status Prescription; Discontinued
ATC Code A04AD12
DrugBank ID DB06717
KEGG ID D06597
MeSH ID C579707
PubChem ID 136086851
TTD Drug ID Not Available
NDC Product Code 0143-9384; 31722-165; 0006-3061; 67184-0540; 70447-0001; 63552-011; 55150-299; 16714-248; 68001-523; 70625-300; 71731-5111; 76339-141; 66039-904; 61662-0007; 0338-0008; 70860-783; 70860-782; 65085-0060; 14501-0064; 0143-9428; 65977-0080; 0781-3484; 52133-0045; 59651-111
Synonyms fosaprepitant | Emend for injection | fosaprepitant dimeglumine | L 785,298 | L785,298 | L-785,298
Chemical Information
Molecular Formula C30H39F7N5O11P
CAS Registry Number 265121-04-8
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C( C=C4)F.CNCC(C(C(C(CO)O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutrophil count decreased13.01.06.010--
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Polydipsia14.05.02.001; 05.03.03.002--Not Available
Polyuria20.02.03.002--Not Available
Prurigo23.03.04.017--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Seborrhoea23.02.07.001--Not Available
Seborrhoeic dermatitis23.03.04.018--Not Available
Sensory disturbance17.02.07.006--Not Available
Shock24.06.02.002--Not Available
Skin disorder23.03.03.007--Not Available
Skin lesion23.03.03.010--Not Available
Sneezing22.02.05.011--
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stomatitis07.05.06.005--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Thirst14.03.02.007; 08.01.09.021--Not Available
Throat irritation22.02.05.013; 07.05.03.004--Not Available
Thrombophlebitis24.01.02.001--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
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