Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fosamprenavir calcium
Drug ID BADD_D00961
Description Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
Indications and Usage Indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission. The use of fosamprenavir is pending revision due to a potential association between the drug and myocardial infarction and dyslipidemia in HIV infected adults.
Marketing Status Prescription
ATC Code J05AE07
DrugBank ID DB01319
KEGG ID D03835
MeSH ID C426859
PubChem ID 131535
TTD Drug ID D0F5MT
NDC Product Code 63379-087; 0378-3520; 63304-583; 49702-207; 49702-208; 65015-806
Synonyms fosamprenavir | fos-amprenavir | (3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester | VX-175 | VX 175 | GW-433908 | GW 908 | GW433908 | GW 433908 | GW-908 | fosamprenavir sodium | GW 433908A | GW-433908A | fosamprenavir calcium | Telzir | GW 433908G | GW-433908G | GW433908G | Lexiva
Chemical Information
Molecular Formula C25H34CaN3O9PS
CAS Registry Number 226700-81-8
SMILES CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)OP(=O)([O-])[O-])S(=O)(=O)C3=CC=C(C=C3) N.[Ca+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insulin resistance14.06.02.003; 05.06.02.003--Not Available
Lipase increased13.05.01.003--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myositis15.05.01.001--
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.004--Not Available
Opportunistic infection11.01.08.007--Not Available
Osteonecrosis24.04.05.004; 15.02.04.007--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rhabdomyolysis15.05.05.002--
Skin disorder23.03.03.007--Not Available
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Vomiting07.01.07.003--
Fat redistribution14.08.04.002--Not Available
Lipodystrophy acquired23.07.01.003; 14.08.04.008--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhage24.07.01.002--Not Available
Paraesthesia oral17.02.06.008; 07.05.03.003--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Inflammation08.01.05.007--Not Available
Malnutrition14.03.02.004--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
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