Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluphenazine
Drug ID BADD_D00935
Description A phenothiazine used in the treatment of psychoses. Its properties and uses are generally similar to those of chlorpromazine.
Indications and Usage For management of manifestations of psychotic disorders.
Marketing Status Discontinued; Prescription
ATC Code N05AB02
DrugBank ID DB00623
KEGG ID D07977
MeSH ID D005476
PubChem ID 3372
TTD Drug ID D0P5SA
NDC Product Code Not Available
Synonyms Fluphenazine | Flufenazin | Fluphenazine Hydrochloride | Hydrochloride, Fluphenazine | Lyogen | Prolixin
Chemical Information
Molecular Formula C22H26F3N3OS
CAS Registry Number 69-23-8
SMILES C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Tardive dyskinesiaD(2) dopamine receptorP14416T6716210821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(3) dopamine receptorP35462T0255110821369; 10379516; 10893495; 9777180; 10889553
Tardive dyskinesiaD(4) dopamine receptorP21917T2498310821369; 10379516; 10893495; 9777180; 10889553
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Seborrhoeic dermatitis23.03.04.018--Not Available
Skin disorder23.03.03.007--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Systemic lupus erythematosus10.04.03.004; 23.03.02.006; 15.06.02.003--Not Available
Tachycardia02.03.02.007--Not Available
Tardive dyskinesia17.01.02.012--Not Available
Tenderness08.01.08.005--Not Available
Throat tightness22.02.05.015; 19.01.02.005--Not Available
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Brain oedema17.07.02.003; 12.01.10.010--
Faecaloma07.01.03.004--Not Available
Faecalith07.01.03.007--Not Available
Purpura non-thrombocytopenic01.01.04.006--Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Urine output increased13.13.03.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Blood disorder01.05.01.004--Not Available
Pigmentation disorder23.05.03.001--Not Available
Liver injury12.01.02.003; 09.01.07.022--Not Available
Brain injury19.07.03.007; 17.11.01.003--Not Available
Acute kidney injury20.01.03.016--
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